{"id":"r-bl-m-04-auto-sct","safety":{"commonSideEffects":[{"rate":"20-50%","effect":"Neutropenia"},{"rate":"10-30%","effect":"Thrombocytopenia"},{"rate":"10-30%","effect":"Anemia"},{"rate":"10-20%","effect":"Nausea and vomiting"},{"rate":"5-15%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of R-BL-M-04 is not well-documented, but it is believed to work by suppressing the immune system and reducing the risk of graft-versus-host disease. This is achieved through a combination of chemotherapy agents that target rapidly dividing cells, including cancer cells and immune cells.","oneSentence":"R-BL-M-04 is a conditioning regimen for auto-SCT, which involves the use of a specific chemotherapy regimen to prepare the patient's body for a stem cell transplant.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:05.190Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Conditioning regimen for auto-SCT"}]},"trialDetails":[{"nctId":"NCT03479918","phase":"PHASE3","title":"R-BL-M-04 Versus R-(DA)-EPOCH and Autologous Stem Cells Transplantation in Patients With High-Grade B-cell Lymphoma Double-hit (HGBL DH) and High-Grade B-cell Lymphoma Not Otherwise Specified (HGBL NOS)","status":"UNKNOWN","sponsor":"Elena N.Parovichnikova","startDate":"2018-03-15","conditions":"Lymphoma, High-Grade","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"R-BL-M-04 + auto-SCT","genericName":"R-BL-M-04 + auto-SCT","companyName":"Elena N.Parovichnikova","companyId":"elena-n-parovichnikova","modality":"Small molecule","firstApprovalDate":"","aiSummary":"R-BL-M-04 is a conditioning regimen for auto-SCT, which involves the use of a specific chemotherapy regimen to prepare the patient's body for a stem cell transplant. Used for Conditioning regimen for auto-SCT.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}