{"id":"quinvaxem-in-single-dose-vials","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Irritability"},{"rate":"5-10","effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Quinvaxem combines conjugated polysaccharide antigens from Haemophilus influenzae type b, Neisseria meningitidis serogroups A and C, Streptococcus pneumoniae, and Vibrio cholerae to elicit protective immunity. The conjugation of polysaccharides to protein carriers enhances immunogenicity, particularly in infants and young children, by promoting T-cell dependent B-cell responses and long-lasting antibody production.","oneSentence":"Quinvaxem is a pentavalent conjugate vaccine that provides immunization against five bacterial pathogens by stimulating antibody and cellular immune responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:31:04.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of invasive disease caused by Haemophilus influenzae type b"},{"name":"Prevention of meningococcal disease (serogroups A and C)"},{"name":"Prevention of pneumococcal disease"},{"name":"Prevention of cholera"}]},"trialDetails":[{"nctId":"NCT01917357","phase":"PHASE3","title":"A Comparison of the Immunogenicity and Safety of Quinvaxem in Mono-dose Vials and Uniject","status":"COMPLETED","sponsor":"Crucell Holland BV","startDate":"2013-09","conditions":"Diphtheria, Pertussis, Tetanus","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Quinvaxem in single dose vials","genericName":"Quinvaxem in single dose vials","companyName":"Crucell Holland BV","companyId":"crucell-holland-bv","modality":"Biologic","firstApprovalDate":"","aiSummary":"Quinvaxem is a pentavalent conjugate vaccine that provides immunization against five bacterial pathogens by stimulating antibody and cellular immune responses. Used for Prevention of invasive disease caused by Haemophilus influenzae type b, Prevention of meningococcal disease (serogroups A and C), Prevention of pneumococcal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}