{"id":"quetiapine-and-topiramate","safety":{"commonSideEffects":[{"rate":null,"effect":"Sedation/somnolence"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Cognitive impairment"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Paresthesias (topiramate)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Quetiapine is an atypical antipsychotic that blocks D2 dopamine and 5-HT2A serotonin receptors, used for psychosis and bipolar disorder. Topiramate is an anticonvulsant that blocks voltage-gated sodium channels and inhibits carbonic anhydrase, providing mood-stabilizing and neuroprotective effects. The combination leverages both agents' psychiatric benefits, though this is an off-label polypharmacy approach rather than a single fixed-dose entity.","oneSentence":"This combination uses quetiapine's dopamine and serotonin antagonism for antipsychotic/mood effects alongside topiramate's sodium channel blockade and carbonic anhydrase inhibition for mood stabilization and anticonvulsant activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:30.891Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bipolar disorder (off-label combination)"},{"name":"Treatment-resistant depression (off-label combination)"},{"name":"Schizophrenia with mood instability (off-label combination)"}]},"trialDetails":[{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":"Dementia, Depression, Schizophrenia","enrollment":407},{"nctId":"NCT00393978","phase":"PHASE4","title":"Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2006-11","conditions":"Bipolar Disorder, Cannabis-Related Disorder","enrollment":75},{"nctId":"NCT00550394","phase":"PHASE4","title":"Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2008-04","conditions":"Bipolar Disorder, Alcohol Abuse","enrollment":56},{"nctId":"NCT00704860","phase":"PHASE4","title":"Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism","status":"COMPLETED","sponsor":"University of Ottawa","startDate":"2005-02","conditions":"Major Depression","enrollment":27},{"nctId":"NCT01000402","phase":"PHASE4","title":"Juvenile Bipolar Disorder Outpatient Program","status":"UNKNOWN","sponsor":"Federal University of Rio Grande do Sul","startDate":"2008-02","conditions":"Bipolar Disorder, Attention Deficit Disorder With Hyperactivity","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Topiramate"],"phase":"marketed","status":"active","brandName":"Quetiapine and Topiramate","genericName":"Quetiapine and Topiramate","companyName":"University of Cincinnati","companyId":"university-of-cincinnati","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses quetiapine's dopamine and serotonin antagonism for antipsychotic/mood effects alongside topiramate's sodium channel blockade and carbonic anhydrase inhibition for mood stabilization and anticonvulsant activity. Used for Bipolar disorder (off-label combination), Treatment-resistant depression (off-label combination), Schizophrenia with mood instability (off-label combination).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}