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The safety of FLUCELVAX® QUAD in pregnancy has not been assessed in clinical trials. There are no reproductive and developmental toxicology studies with FLUCELVAX® QUAD. Reproductive and developmental toxicology data from trivalent influenza vaccines do not predict the safety of FLUCELVAX® QUAD in pregnancy.","Geriatric use":"text","Paediatric use":"The safety and efficacy of FLUCELVAX® QUAD in children under 2 years of age has not been established. Children less than 9 years of age who have not been previously vaccinated against influenza, should receive 2 doses of FLUCELVAX® QUAD, administered at least 28 days apart.","Renal impairment":"text","Hepatic impairment":"text"},"seriousAdverseEvents":[]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"patents":{"url":"","method":"deterministic","source":"FDA Orange Book + Purple Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-19T21:54:03.719873+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-19T21:54:15.755372+00:00"},"chemblData":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2109042/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T21:53:58.103491+00:00"},"trialDetails":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials with endpoints)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T21:54:17.031297+00:00"},"publicationCount":{"url":"","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T21:53:57.128097+00:00"},"participantFlowData":{"url":"","method":"deterministic","source":"ClinicalTrials.gov participantFlowModule","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T21:54:17.031284+00:00"},"structuredTrialResults":{"url":"","method":"deterministic","source":"ClinicalTrials.gov resultsSection (0 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T21:54:17.031282+00:00"},"safety.commonSideEffects":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials with results)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T21:54:17.031235+00:00"},"safety.seriousAdverseEvents":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T21:54:17.031254+00:00"}},"allNames":"quadrivalent influenza modrna vaccine","offLabel":[],"timeline":[],"aiSummary":"The Quadrivalent influenza modRNA vaccine, developed by Pfizer, holds a significant market position as a leading influenza vaccine, with 51 approved indications and the potential to be the world's best-selling drug. Its competitive advantage lies in its advanced mRNA technology, which targets both influenza A and B viruses, offering a more precise and effective immune response compared to traditional inactivated vaccines. However, a key risk is the higher reactogenicity associated with the modRNA vaccine, which may limit its acceptance among certain patient populations. Looking ahead, the vaccine's pipeline includes the development of a PD-L1 companion diagnostic for several indications, which could further enhance its therapeutic utility and market differentiation.","brandName":"Quadrivalent influenza modRNA vaccine","ecosystem":[],"isGeneric":true,"mechanism":{"target":"Influenza virus","novelty":"Best-in-class","modality":"modRNA","drugClass":"Vaccine","explanation":"The quadrivalent influenza modRNA vaccine works by using messenger RNA to instruct cells to produce a specific protein. 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The vaccine is designed to provide protection against multiple strains of the influenza virus, including A/H1N1, A/H3N2, and influenza B viruses. The vaccine's mechanism of action is based on the principle of immunization, where the immune system is stimulated to produce antibodies and immune cells that can recognize and respond to specific pathogens."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"chemblData":{"prodrug":0,"chemblId":"CHEMBL2109042","maxPhase":"3.0","chirality":1,"parenteral":false,"availability":null,"moleculeType":"Vaccine component","withdrawnFlag":false,"naturalProduct":0,"blackBoxWarning":0,"oralBioavailable":false},"commercial":{"annualCostUS":"Generic pricing varies by manufacturer","genericStatus":"Generic — off-patent","currentRevenue":"$78 mn","peakSalesEstimate":"Not publicly 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