{"id":"pyrrocaine","rwe":[{"pmid":"6838647","year":"1983","title":"Study of anaesthetic agents for their ability to elicit porphyrin biosynthesis in chick embryo liver.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"270977","year":"1977","title":"A rapid spectrophotometric assay of amide type dental anaesthetic agents.","finding":"","journal":"Australian dental journal","studyType":"Clinical Study"},{"pmid":"4883831","year":"1969","title":"Double-blind evaluation of a new local anesthetic agents, pyrrocaine hydrochloride, for nerve block anesthesia.","finding":"","journal":"Anesthesia and analgesia","studyType":"Clinical Study"},{"pmid":"19598995","year":"1963","title":"Pyrrocaine HCl - A Preliminary Clinical Study of Its Uses in Oral Surgery.","finding":"","journal":"Journal of the American Dental Society of Anesthesiology","studyType":"Clinical Study"}],"tags":[{"label":"pyrrocaine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"endocaine","offLabel":[],"synonyms":["pyrrocaine monohydrochloride","pyrrocaine hydrochloride","pyrrocaine","endocaine","pirothesin"],"timeline":[],"approvals":[],"brandName":"Endocaine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"pyrrocaine","explanation":"Imagine your nerves are like electrical wires. Sodium channels are like the switches that control the flow of electricity. When Endocaine blocks these switches, it can help reduce pain by limiting the electrical signals that are sent to the brain.","oneSentence":"Endocaine works by blocking sodium channels in the nervous system.","technicalDetail":"Endocaine exerts its effects by selectively binding to and inhibiting voltage-gated sodium channels, which are critical for the initiation and propagation of action potentials in neurons."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3512","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PYRROCAINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:31:37.051601","biosimilars":[],"competitors":[],"genericName":"pyrrocaine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"9D47L94CPW","CHEBI":"CHEBI:134946","INN_ID":"1363","UMLSCUI":"C0609331","ChEMBL_ID":"CHEMBL1895219","KEGG_DRUG":"D05665","PUBCHEM_CID":"24361","SECONDARY_CAS_RN":"2210-64-2","MESH_SUPPLEMENTAL_RECORD_UI":"C022845"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1983 Mar 15","pmid":"6838647","title":"Study of anaesthetic agents for their ability to elicit porphyrin biosynthesis in chick embryo liver.","journal":"Biochemical pharmacology"},{"date":"1977 Jun","pmid":"270977","title":"A rapid spectrophotometric assay of amide type dental anaesthetic agents.","journal":"Australian dental journal"},{"date":"1969 Jan-Feb","pmid":"4883831","title":"Double-blind evaluation of a new local anesthetic agents, pyrrocaine hydrochloride, for nerve block anesthesia.","journal":"Anesthesia and analgesia"},{"date":"1963 Oct","pmid":"19598995","title":"Pyrrocaine HCl - A Preliminary Clinical Study of Its Uses in Oral Surgery.","journal":"Journal of the American Dental Society of Anesthesiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Endocaine, also known as Pyrrocaine, is a small molecule drug in the pyrrocaine class. Its exact target and mechanism of action are unknown, but it is believed to work by blocking sodium channels in the nervous system. Endocaine is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. As a result, key safety considerations and pharmacokinetic properties, such as half-life and bioavailability, are also unknown. Further research is needed to fully understand Endocaine's properties and potential uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}