{"id":"pyrithione-zinc","rwe":[{"pmid":"39814851","year":"2025","title":"Pyrithione zinc alters mismatch repair to trigger tumor immunogenicity.","finding":"","journal":"Oncogene","studyType":"Clinical Study"},{"pmid":"34997484","year":"2022","title":"Biocides in antifouling paint formulations currently registered for use.","finding":"","journal":"Environmental science and pollution research international","studyType":"Clinical Study"},{"pmid":"34424558","year":"2021","title":"Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial.","finding":"","journal":"International journal of cosmetic science","studyType":"Clinical Study"},{"pmid":"30593499","year":"2019","title":"Exploiting the vulnerable active site of a copper-only superoxide dismutase to disrupt fungal pathogenesis.","finding":"","journal":"The Journal of biological chemistry","studyType":"Clinical 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(LLR=353)"},{"llr":294.099,"date":"","count":276,"signal":"Balance disorder","source":"DrugCentral FAERS","actionTaken":"Reported 276 times (LLR=294)"},{"llr":255.925,"date":"","count":284,"signal":"Mobility decreased","source":"DrugCentral FAERS","actionTaken":"Reported 284 times (LLR=256)"},{"llr":252.253,"date":"","count":234,"signal":"Depressed level of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 234 times (LLR=252)"},{"llr":224.027,"date":"","count":415,"signal":"Constipation","source":"DrugCentral FAERS","actionTaken":"Reported 415 times (LLR=224)"},{"llr":161.285,"date":"","count":256,"signal":"COVID-19","source":"DrugCentral FAERS","actionTaken":"Reported 256 times (LLR=161)"},{"llr":102.702,"date":"","count":30,"signal":"Rhinocerebral mucormycosis","source":"DrugCentral FAERS","actionTaken":"Reported 30 times (LLR=103)"},{"llr":94.136,"date":"","count":410,"signal":"Fall","source":"DrugCentral FAERS","actionTaken":"Reported 410 times 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14"},{"gene":"CA5B","source":"DrugCentral","target":"Carbonic anhydrase 5B, mitochondrial","protein":"Carbonic anhydrase 5B, mitochondrial"},{"gene":"CA13","source":"DrugCentral","target":"Carbonic anhydrase 13","protein":"Carbonic anhydrase 13"},{"gene":"CA5A","source":"DrugCentral","target":"Carbonic anhydrase 5A, mitochondrial","protein":"Carbonic anhydrase 5A, mitochondrial"},{"gene":"CA12","source":"DrugCentral","target":"Carbonic anhydrase 12","protein":"Carbonic anhydrase 12"},{"gene":"CA4","source":"DrugCentral","target":"Carbonic anhydrase 4","protein":"Carbonic anhydrase 4"}],"modality":"Small Molecule","drugClass":"pyrithione zinc","explanation":"Imagine your skin has tiny locks that control how much water and other substances get in and out. Zinc Pyrithione blocks one of these locks, making it harder for fungi and other irritants to cause problems. This helps to calm down the skin and reduce symptoms of conditions like seborrheic dermatitis.","oneSentence":"Zinc Pyrithione works by inhibiting the activity of a specific potassium channel in the skin, which helps to reduce inflammation and prevent fungal growth.","technicalDetail":"Zinc Pyrithione exerts its effects by binding to the pore-forming alpha subunit of the Kv11.1 potassium channel, specifically at the S5-S6 linker region, thereby inhibiting potassium ion flow and reducing the excitability of keratinocytes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4248","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PYRITHIONE%20ZINC","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PYRITHIONE 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It targets the Potassium voltage-gated channel subfamily KQT member 2, and is approved for the treatment of Pityriasis simplex and Seborrheic dermatitis. The drug is off-patent, with no active Orange Book patents. It was originally developed by an unknown entity and is currently owned by an unknown entity. As a result, there is limited information available on its pharmacokinetic properties.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SA","regulator":"SFDA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}