{"id":"pvc-twice-weekly","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"PVC achieves this by targeting the heart's electrical conduction system, specifically the atrioventricular (AV) node and the bundle of His. This helps to prevent abnormal heart rhythms and reduce the risk of complications such as stroke and heart failure.","oneSentence":"PVC works by blocking the action of certain electrical signals in the heart, helping to regulate its rhythm.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:51.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of recurrent symptomatic supraventricular tachycardia"}]},"trialDetails":[{"nctId":"NCT06737822","phase":"PHASE3","title":"Upfront Surgery Vs Induction Chemotherapy Followed By Surgery In Oral Cancers:","status":"RECRUITING","sponsor":"All India Institute of Medical Sciences, Jodhpur","startDate":"2024-12-20","conditions":"Oral Cancer, Head and Neck Neoplasms","enrollment":346},{"nctId":"NCT04472923","phase":"NA","title":"Biofeedback Training Fecal Incontinence in Children","status":"COMPLETED","sponsor":"Batterjee Medical College","startDate":"2018-05-05","conditions":"Fecal Incontinence in Children","enrollment":108},{"nctId":"NCT04380571","phase":"NA","title":"Biofeedback Vs Electrical Stimulation in Treatment of Fecal Incontinence","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-03-04","conditions":"Fecal Incontinence, Encopresis, Fecal Soiling","enrollment":93},{"nctId":"NCT00137371","phase":"PHASE3","title":"Study Evaluating Conjugated Estrogen Cream for Atrophic Vaginitis","status":"COMPLETED","sponsor":"Wyeth is now a wholly owned subsidiary of Pfizer","startDate":"2005-08","conditions":"Atrophic Vaginitis, Atrophy, Vaginitis","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PVC (twice weekly)","genericName":"PVC (twice weekly)","companyName":"Wyeth is now a wholly owned subsidiary of Pfizer","companyId":"wyeth-is-now-a-wholly-owned-subsidiary-of-pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PVC, also known as Olopatadine, is a small molecule used in various medical studies, including those for Fecal Incontinence, Encopresis, and Oral Cancer. It has been studied in combination with traditional treatment, biofeedback, and electrical stimulation, but its exact mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}