{"id":"purethal-mites","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (itching, swelling, erythema)"},{"rate":null,"effect":"Oral pruritus or throat irritation"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Rhinitis or asthma exacerbation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is an allergen extract-based immunotherapy that works by gradually exposing patients to standardized dust mite allergen components, promoting immune tolerance and reducing allergic responses. The mechanism involves shifting the immune response from Th2-mediated (allergic) to Th1-mediated (tolerant) pathways, potentially involving regulatory T cell induction and IgG blocking antibody production.","oneSentence":"Purethal Mites is an allergen immunotherapy product designed to desensitize patients to dust mite allergens through controlled exposure.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:30:50.217Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or asthma induced by dust mite allergens"}]},"trialDetails":[{"nctId":"NCT06920771","phase":"PHASE3","title":"A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess the Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects With Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma Induced by House Dust Mite (HDM)","status":"ACTIVE_NOT_RECRUITING","sponsor":"HAL Allergy","startDate":"2024-09-09","conditions":"House Dust Mite Allergy, House Dust Mite Rhinitis","enrollment":552},{"nctId":"NCT03209245","phase":"PHASE3","title":"House Dust Mite Injection Immunotherapy in Elderly Patients.","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2014-04-10","conditions":"Allergen Immunotherapy in Elderly Patients","enrollment":58},{"nctId":"NCT01438463","phase":"PHASE2","title":"PURETHAL® Mites Dose Range Finding Study in Patients With Persistent Allergic Rhinitis/Rhinoconjunctivitis","status":"COMPLETED","sponsor":"HAL Allergy","startDate":"2011-09","conditions":"Allergic Rhinitis, Allergic Rhinoconjunctivitis","enrollment":290},{"nctId":"NCT00973453","phase":"PHASE2","title":"Study With High Dose PURETHAL Mites in Allergic Rhinitis/Rhinoconjunctivitis Patients","status":"COMPLETED","sponsor":"HAL Allergy","startDate":"2009-08","conditions":"Allergic Rhinitis, Allergic Rhinoconjunctivitis","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Purethal Mites","genericName":"Purethal Mites","companyName":"Medical University of Silesia","companyId":"medical-university-of-silesia","modality":"Biologic","firstApprovalDate":"","aiSummary":"Purethal Mites is an allergen immunotherapy product designed to desensitize patients to dust mite allergens through controlled exposure. Used for Allergic rhinitis and/or asthma induced by dust mite allergens.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}