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Exogenous surfactant replacement restores this function in conditions where surfactant is deficient or inactivated.","oneSentence":"Replaces deficient or dysfunctional endogenous lung surfactant to reduce alveolar surface tension and prevent alveolar collapse during respiration."},"_scrapedAt":"2026-03-28T01:30:49.234Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779122747,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"beractant","brand":"Survanta","company":"AbbVie","rationale":"Bovine-derived surfactant for neonatal RDS"},{"name":"poractant alfa","brand":"Curosurf","company":"Chiesi","rationale":"Porcine-derived surfactant for neonatal RDS"},{"name":"calfactant","brand":"Infasurf","company":"ONY Biotech","rationale":"Calf lung-derived surfactant for neonatal RDS"}],"description":"Pulmonary surfactant is a biological substance that reduces surface tension in the lungs, enabling proper breathing. It is used therapeutically to treat respiratory distress syndrome in premature infants and is being investigated for acute respiratory distress syndrome in adults and other pulmonary conditions.","indications":{"approved":[{"status":"approved","condition":"Neonatal respiratory distress syndrome","patientPopulation":"Premature infants"},{"status":"investigational","condition":"Acute respiratory distress syndrome (ARDS)","patientPopulation":"Adult"},{"status":"investigational","condition":"Meconium aspiration syndrome","patientPopulation":"Neonatal"}]},"trialDetails":[{"nctId":"NCT06554522","phase":"PHASE4","title":"Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa","status":"RECRUITING","sponsor":"Indiana University","startDate":"2025-01-01","conditions":"Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal","enrollment":1512},{"nctId":"NCT03822780","phase":"NA","title":"Hydroxychloroquin (HCQ) in chILD of 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(HMD)","enrollment":145},{"nctId":"NCT03877991","phase":"EARLY_PHASE1","title":"Bioequivalence Assessment of Cannabidiol (CBD) Administrated in Oral Formulations","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2024-02-19","conditions":"Pain","enrollment":12},{"nctId":"NCT06491901","phase":"NA","title":"Prospective, Non-Blinded, Randomized Controlled Trial on Early Administration of Pulmonary Surfactant Guided by Lung Ultrasound Scores in Very Preterm Infants.","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2024-08-01","conditions":"Early Administration of Pulmonary Surfactant Guided by Lung Ultrasound Scores in Very Preterm Infants","enrollment":60},{"nctId":"NCT06090981","phase":"NA","title":"Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome","status":"COMPLETED","sponsor":"Lady Hardinge Medical College","startDate":"2022-03-12","conditions":"Meconium 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