{"id":"provarix","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain"},{"rate":null,"effect":"Injection site erythema"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains recombinant VZV glycoprotein E (gE) combined with an AS01B adjuvant system to enhance immune response. It stimulates both cellular and humoral immunity against VZV, providing protection against reactivation of latent virus that causes shingles and its complications.","oneSentence":"PROVARIX is a recombinant varicella-zoster virus (VZV) vaccine designed to prevent herpes zoster (shingles) and post-herpetic neuralgia in immunocompetent and immunocompromised populations.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:03.029Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of herpes zoster (shingles) in adults aged 50 years and older"},{"name":"Prevention of post-herpetic neuralgia in adults aged 50 years and older"}]},"trialDetails":[{"nctId":"NCT07475000","phase":"PHASE3","title":"Second Dose of Varicella Vaccine in Healthy Children","status":"RECRUITING","sponsor":"Sinovac (Dalian) Vaccine Technology Co., Ltd.","startDate":"2026-01-28","conditions":"Varicella (Chickenpox), Varicella Immunisation","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PROVARIX","genericName":"PROVARIX","companyName":"Sinovac (Dalian) Vaccine Technology Co., Ltd.","companyId":"sinovac-dalian-vaccine-technology-co-ltd","modality":"Biologic","firstApprovalDate":"","aiSummary":"PROVARIX is a recombinant varicella-zoster virus (VZV) vaccine designed to prevent herpes zoster (shingles) and post-herpetic neuralgia in immunocompetent and immunocompromised populations. Used for Prevention of herpes zoster (shingles) in adults aged 50 years and older, Prevention of post-herpetic neuralgia in adults aged 50 years and older.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}