{"id":"prothrombin-time","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2108764","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PT measures the activity of coagulation factors I, II, V, VII, and X by adding tissue factor and calcium to citrated plasma and timing clot formation. It is primarily used to monitor anticoagulation therapy with warfarin and other vitamin K antagonists, and to assess bleeding risk or liver function. The test is not a drug itself but rather a diagnostic assay used to guide therapeutic decisions.","oneSentence":"Prothrombin time (PT) is a laboratory test that measures the time it takes for blood plasma to clot, reflecting the function of extrinsic and common coagulation pathway factors.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:03:09.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Prothrombin_time","title":"Prothrombin time","extract":"The prothrombin time (PT) – along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) – is an assay for evaluating the extrinsic pathway and common pathway of coagulation. This blood test is also called protime INR and PT/INR. They are used to determine the clotting tendency of blood, in conditions such as the measure of warfarin dosage, liver damage (cirrhosis), and vitamin K status. PT measures the following coagulation factors: I (fibrinogen), II (prothrombin), V (proaccelerin), VII (proconvertin), and X."},"indications":{"approved":[{"name":"Monitoring anticoagulation therapy with warfarin and vitamin K antagonists"},{"name":"Assessment of bleeding risk and coagulation disorders"},{"name":"Evaluation of liver function"}]},"trialDetails":[{"nctId":"NCT05124041","phase":"NA","title":"Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2021-11-15","conditions":"Acute on Chronic Liver Failure, Variceal Hemorrhage, Cirrhosis, Liver","enrollment":262},{"nctId":"NCT07101926","phase":"","title":"Monitoring of Anti-TFPI in Hemophilia","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2025-10-23","conditions":"Hemophilia, Rebalancing Agents, Prophylaxis","enrollment":11},{"nctId":"NCT06883240","phase":"","title":"An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment","status":"RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2025-04-29","conditions":"Von Willebrand Disease, Type 3","enrollment":40},{"nctId":"NCT03560570","phase":"","title":"Study of Hemostasis in Patients With Congenital Disorder of Glycosylation","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2014-01-01","conditions":"Congenital Disorders of Glycosylation","enrollment":57},{"nctId":"NCT07418099","phase":"","title":"External Multicenter Validation of the APTTO Model for Prolonged APTT Using Clot Waveform Analysis","status":"RECRUITING","sponsor":"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz","startDate":"2026-01-13","conditions":"Coagulation Disorder, Blood, Prolonged APTT","enrollment":1500},{"nctId":"NCT07422974","phase":"","title":"Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer","status":"RECRUITING","sponsor":"Osijek University Hospital","startDate":"2026-01-09","conditions":"Colorectal Carcinoma (CRC), Complications, Neoadjuvant Therapy","enrollment":68},{"nctId":"NCT06429332","phase":"PHASE4","title":"International Care Bundle Evaluation in Cerebral Hemorrhage Research","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-01-07","conditions":"Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage","enrollment":3500},{"nctId":"NCT07023354","phase":"PHASE1","title":"A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems","status":"RECRUITING","sponsor":"Boehringer Ingelheim","startDate":"2025-06-25","conditions":"Healthy, Hepatic Impairment","enrollment":32},{"nctId":"NCT04680728","phase":"","title":"Venous Congestion and Organ Dysfunction.","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2020-10-06","conditions":"Venous Congestion, Organ Dysfunction Syndrome","enrollment":185},{"nctId":"NCT07346014","phase":"NA","title":"Sleep and Circadian Interventions for College Students at High Risk of Suicide","status":"NOT_YET_RECRUITING","sponsor":"University of Pittsburgh","startDate":"2026-03","conditions":"Sleep Disturbance, Sleep, Depression","enrollment":90},{"nctId":"NCT04268940","phase":"","title":"Thrombo-Elastography Guided Management of ECMO","status":"COMPLETED","sponsor":"Damian Ratano","startDate":"2020-06-03","conditions":"Extracorporeal Circulation of Blood; Thrombocytopenia","enrollment":61},{"nctId":"NCT07342127","phase":"","title":"Evaluation of a Preventive Therapeutic Strategy for Postpartum Venous Thromboembolism in Women With Genetic Risk Factor","status":"NOT_YET_RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2026-02-01","conditions":"Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation, Pregnancy","enrollment":100},{"nctId":"NCT07336095","phase":"PHASE3","title":"Melatonin vs Midazolam in Children Undergoing Tonsillectomy","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-03-01","conditions":"Emergence Delirium, Anesthesia, Child, Anxiety","enrollment":195},{"nctId":"NCT00508924","phase":"PHASE2","title":"Study on Safety and Effectiveness of Three Doses of Argatroban as Anticoagulant in Percutaneous Coronary Intervention (PCI)","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2005-08","conditions":"Coronary Artery Disease, Angina, Unstable","enrollment":140},{"nctId":"NCT02352181","phase":"NA","title":"Management of Coagulopathy During Orthotopic Liver Transplantation. 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