{"id":"prothrombin","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"marketed","safety":{"commonSideEffects":[{"effect":"Anemia","drugRate":"5.7%","severity":"common","organSystem":""},{"effect":"Procedural pain","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Wound complications","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Asthenia","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Dysuria","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Procedural vomiting","drugRate":"3%","severity":"common","organSystem":""},{"effect":"Catheter site related reaction","drugRate":"3%","severity":"common","organSystem":""}],"seriousAdverseEvents":[{"effect":"Death","drugRate":"3.8%","severity":"serious"},{"effect":"Thromboembolic events","drugRate":"2.9%","severity":"serious"},{"effect":"Cerebral infarction","drugRate":"1%","severity":"serious"},{"effect":"Pulmonary embolism","drugRate":"1%","severity":"serious"},{"effect":"Unstable angina","drugRate":"1%","severity":"serious"},{"effect":"Hemorrhage","drugRate":"1%","severity":"serious"},{"effect":"Acute respiratory failure","drugRate":"1%","severity":"serious"},{"effect":"Shock","drugRate":"1%","severity":"serious"},{"effect":"Subdural hemorrhage","drugRate":"1%","severity":"serious"},{"effect":"Myocardial ischemia","drugRate":"1%","severity":"serious"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PROTHROMBIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:14:19.474867+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:14:25.909160+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PROTHROMBIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:14:26.726394+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108764/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:14:27.209465+00:00"}},"allNames":["prothrombin"],"offLabel":[],"synonyms":[],"timeline":[],"aiSummary":"Prothrombin is a protein involved in blood clotting. It is a precursor to thrombin, which converts fibrinogen into fibrin, forming a blood clot. However, there is no information available on a pharmaceutical product called 'prothrombin'. Therefore, this summary will be based on the general concept of prothrombin. In the context of a pharmaceutical product, it is likely that a prothrombin-related product would be used to treat bleeding disorders or prevent excessive bleeding.","approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Prothrombin is a vitamin K-dependent glycoprotein that is converted into thrombin by the enzyme factor Xa. Thrombin then catalyzes the conversion of fibrinogen into fibrin, which polymerizes to form a blood clot."},"commercial":{},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=prothrombin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=prothrombin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-31T10:34:27.636742","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:14:29.366398+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"prothrombin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05124041","phase":"NA","title":"Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, 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