{"id":"protheobromine","rwe":[],"tags":[{"label":"protheobromine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":["NCT02135263","NCT03949075"],"aliases":[],"patents":[],"pricing":[],"allNames":"corodil","offLabel":[],"synonyms":["protheobromine","cordabromin","cordaleromin","corodil","pantobromina","protheobromin"],"timeline":[],"approvals":[],"brandName":"Corodil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"protheobromine","explanation":"Imagine your body's cells are like a factory, and protheobromine is a tool that helps adjust the factory's production line. By influencing the enzymes and receptors, protheobromine may help regulate various bodily processes, but the exact details of how it does this are still unclear.","oneSentence":"Protheobromine is thought to work by modulating the activity of certain enzymes or receptors in the body.","technicalDetail":"Protheobromine is a small molecule that may interact with specific enzymes or receptors, potentially altering their activity and influencing downstream signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3497","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PROTHEOBROMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:30:49.111283","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"protheobromine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02135263","phase":"Phase 4","title":"Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype","status":"COMPLETED","sponsor":"Bispebjerg Hospital","isPivotal":false,"enrollment":44,"indication":"Carboxylesterase 1 (CES1) Genotype, CES1 Activity","completionDate":"2014-05"},{"nctId":"NCT03949075","phase":"NA","title":"Impact of Angiotensin Converting Enzyme Activity on Exercise Training Sensitivity","status":"COMPLETED","sponsor":"University of Copenhagen","isPivotal":false,"enrollment":52,"indication":"Exercise, Angiotensin-Converting Enzyme Inhibitors","completionDate":"2019-12-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"8067S1388X","CHEBI":"CHEBI:134969","INN_ID":"1666","UMLSCUI":"C2698905","ChEMBL_ID":"CHEMBL85140","PUBCHEM_CID":"66120"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Corodil, also known as protheobromine, is a small molecule drug of the protheobromine class. Its exact target and mechanism of action are unknown, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety profile. Further research is needed to fully understand the properties and potential uses of Corodil. It is not currently available as a generic medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}