{"id":"protamine-ratio-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dyspnea"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Anaphylaxis (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Protamine sulfate is used as an antidote to reverse heparin anticoagulation. It works by electrostatically binding to negatively charged heparin molecules, forming a stable complex that is then cleared from the body. The 'ratio dose' refers to dosing calculations based on the amount of heparin that needs to be reversed, typically using a 1:1 mg ratio (1 mg protamine per 100 units of heparin).","oneSentence":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:13.411Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of heparin anticoagulation in patients requiring urgent reversal of anticoagulant effects"}]},"trialDetails":[{"nctId":"NCT07477977","phase":"NA","title":"Dose for Reversal of Heparin After Cardiopulmonary Bypass","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2026-03-01","conditions":"Open Heart Surgery","enrollment":195},{"nctId":"NCT05426031","phase":"PHASE4","title":"Optimal Protamine Dosing for Heparin Reversal Following Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"University of Miami","startDate":"2022-06-28","conditions":"Coagulation; Intravascular","enrollment":130},{"nctId":"NCT02557672","phase":"PHASE4","title":"PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2016-08","conditions":"Bleeding, Blood Loss, Surgical, Cardiovascular Surgical Procedures","enrollment":106},{"nctId":"NCT03347201","phase":"NA","title":"Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management.","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2017-10-02","conditions":"Cardiac Surgery","enrollment":100},{"nctId":"NCT03532594","phase":"NA","title":"Algorithmic Protamine Dosing for Reversal of Heparin After Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Papworth Hospital NHS Foundation Trust","startDate":"2018-04-16","conditions":"Heart Diseases, Cardiovascular Diseases","enrollment":228},{"nctId":"NCT02449603","phase":"PHASE4","title":"Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes","status":"COMPLETED","sponsor":"Xijing Hospital","startDate":"2015-11","conditions":"Type 2 Diabetes Mellitus","enrollment":150},{"nctId":"NCT00807092","phase":"PHASE4","title":"Comparing the Efficacy and Safety of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 on Blood Sugar Control in Subjects With Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2008-12","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":145},{"nctId":"NCT01267487","phase":"PHASE4","title":"Clinical Trial Comparing Heparin and Protamine Fixed and Titrated Doses in Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"SANE-Society of Anesthesiology","startDate":"2009-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass, Anticoagulation","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Protamine ratio dose","genericName":"Protamine ratio dose","companyName":"University of Miami","companyId":"university-of-miami","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Protamine is a positively charged protein that binds to and neutralizes the anticoagulant effects of heparin by forming an inactive complex. Used for Reversal of heparin anticoagulation in patients requiring urgent reversal of anticoagulant effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}