{"id":"prostin-pge2-tablets","safety":{"commonSideEffects":[{"rate":"12-15","effect":"Apnea"},{"rate":"14-16","effect":"Fever"},{"rate":"7-12","effect":"Hypotension"},{"rate":"2-5","effect":"Diarrhea"},{"rate":"5-10","effect":"Flushing"}]},"_chembl":{"chemblId":"CHEMBL344566","moleculeType":"Small molecule","molecularWeight":"378.51"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PGE2 (dinoprostone) acts as a prostanoid receptor agonist, primarily targeting EP receptors on vascular smooth muscle and platelets. This leads to increased cAMP levels, resulting in vasodilation, reduced platelet aggregation, and improved microcirculation. The drug is used to maintain ductal arteriosus patency in neonates and for other vascular indications.","oneSentence":"Prostin (PGE2) is a prostaglandin E1 analog that binds to prostaglandin receptors to promote vasodilation, inhibit platelet aggregation, and improve blood flow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:03:07.497Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Patent ductus arteriosus (PDA) in neonates"},{"name":"Peripheral vascular disease and intermittent claudication"}]},"trialDetails":[{"nctId":"NCT03471858","phase":"NA","title":"Mechanical Dilation of the Cervix in a Scarred Uterus","status":"COMPLETED","sponsor":"Ministry of Health, Singapore","startDate":"2019-08-29","conditions":"Pregnancy Related, Labor Complication, Cesarean Section; Dehiscence","enrollment":44},{"nctId":"NCT02956785","phase":"PHASE2","title":"What After the First Propess","status":"TERMINATED","sponsor":"South Warwickshire NHS Foundation Trust","startDate":"2017-01","conditions":"Induction of Labor","enrollment":85},{"nctId":"NCT04500496","phase":"NA","title":"Vaginal Dinoprostone Versus Isonicotinic Acid Hydrazide Prior to Diagnostic Office Hysteroscopy","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"Postmenopausal Bleeding","enrollment":200},{"nctId":"NCT04743297","phase":"PHASE4","title":"Propess Versus Prostin for Induction of Labour in Women With Term PROM","status":"UNKNOWN","sponsor":"University Medical Centre Maribor","startDate":"2021-03","conditions":"Premature Rupture of Membranes at Term, Induction of Labour","enrollment":526},{"nctId":"NCT04044079","phase":"PHASE4","title":"Vaginal Dinoprostone Versus Vaginal Misoprostol Prior to Diagnostic Office Hysteroscopy in Postmenopausal Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-08-20","conditions":"Office Hysteroscopy","enrollment":150},{"nctId":"NCT04505943","phase":"NA","title":"Vaginal Misoprostol and Dinoprostone and Isonicotinic Acid Hydrazide Prior to Copper Intrauterine Device Insertion","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"IUCD Complication","enrollment":200},{"nctId":"NCT04505917","phase":"NA","title":"Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"IUCD Complication","enrollment":200},{"nctId":"NCT04079140","phase":"PHASE4","title":"Vaginal Dinoprostone Administration Prior to Intrauterine Device Insertion","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-09-15","conditions":"IUD Insertion Pain","enrollment":130},{"nctId":"NCT03686085","phase":"PHASE3","title":"Vaginal Dinoprostone Administration Prior to a T380A Intrauterine Device Insertion in Nulliparous Women.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-09-30","conditions":"Intrauterine Device","enrollment":200},{"nctId":"NCT04080336","phase":"PHASE4","title":"Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Nulliparous Women","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-09-10","conditions":"IUD Insertion Complication","enrollment":129},{"nctId":"NCT04046302","phase":"PHASE4","title":"Vaginal Dinoprostone Administration Prior to an Intrauterine Device Insertion in Multiparous Women.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-08-30","conditions":"IUD Insertion","enrollment":160},{"nctId":"NCT04045548","phase":"PHASE4","title":"Vaginal Dinoprostone Administration Prior to Insertion Levonorgestrel-releasing Intrauterine System in Women With no Previous Vaginal Delivery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-08-10","conditions":"Intrauterine Device","enrollment":200},{"nctId":"NCT04080349","phase":"PHASE4","title":"Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women Delivered Only by Cesarean Delivery","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-09-10","conditions":"IUD Pain","enrollment":300},{"nctId":"NCT04042974","phase":"PHASE4","title":"Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Primarily Infertile Patients","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-08-10","conditions":"Hysteroscopy","enrollment":100},{"nctId":"NCT03683914","phase":"PHASE4","title":"Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Postmenopausal Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-09-30","conditions":"Office Hysteroscopy","enrollment":102},{"nctId":"NCT02620215","phase":"PHASE4","title":"Cervical Ripening Balloon in Induction of Labour at Term","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2015-11","conditions":"Pregnancy","enrollment":417},{"nctId":"NCT03489928","phase":"PHASE3","title":"Misoprostol Labour Induction Study","status":"COMPLETED","sponsor":"David Young","startDate":"1999-04-01","conditions":"Induction of Labour, Labour, Induced","enrollment":511},{"nctId":"NCT02486679","phase":"PHASE4","title":"A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction","status":"UNKNOWN","sponsor":"Wolfson Medical Center","startDate":"2015-07","conditions":"Labor, Induced","enrollment":300},{"nctId":"NCT01635439","phase":"PHASE3","title":"Prostin and Propess in Induction of Labor","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2010-12","conditions":"Labor Pain","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Prostin (PGE2) tablets","genericName":"Prostin (PGE2) tablets","companyName":"Wolfson Medical Center","companyId":"wolfson-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prostin (PGE2) is a prostaglandin E1 analog that binds to prostaglandin receptors to promote vasodilation, inhibit platelet aggregation, and improve blood flow. Used for Patent ductus arteriosus (PDA) in neonates, Peripheral vascular disease and intermittent claudication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}