{"id":"prostaglandin-e2-propess","brandName":"Prostaglandin E2 (Propess)","genericName":"Prostaglandin E2 (Propess)","companyId":"university-medical-centre-maribor","companyName":"University Medical Centre Maribor","phase":"marketed","status":"active","modality":"Small molecule","aliases":["dinoprostone"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Prostaglandin E2 (Propess) is a cervical ripening agent used in obstetrics. It is under investigation for various indications, including labor induction in term pregnancies. The drug has a strong clinical trial presence but lacks FDA approval. Safety concerns include common side effects like uterine hyperstimulation and fetal distress.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PGE2 is a naturally occurring eicosanoid that activates EP1, EP2, EP3, and EP4 receptors on myometrial and cervical cells. This receptor activation increases intracellular calcium and promotes myometrial contractions while simultaneously softening and dilating the cervix through remodeling of collagen and increased tissue compliance. The Propess formulation delivers PGE2 via a vaginal insert for sustained local release.","oneSentence":"Prostaglandin E2 (PGE2) binds to prostaglandin E receptors on uterine smooth muscle and cervical tissue to promote uterine contractions and cervical ripening.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"5-10","effect":"Uterine hyperstimulation with fetal heart rate changes"},{"rate":"5-15","effect":"Vaginal pain or discomfort"},{"rate":"5-10","effect":"Fever"},{"rate":"5","effect":"Nausea"},{"rate":"3-5","effect":"Diarrhea"},{"rate":"3-5","effect":"Back pain"}]},"trials":[],"indications":{"approved":[{"name":"Cervical ripening and induction of labor in pregnant women at or near term with a medical indication for labor induction"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}