{"id":"prosicca-sine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Eye irritation"},{"rate":null,"effect":"Foreign body sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug consists of a mucin-containing polymer that adheres to the corneal and conjunctival epithelium, forming a protective layer that reduces friction, maintains moisture, and protects against further epithelial damage. By mimicking natural tear film components, it provides symptomatic relief and supports ocular surface healing in patients with severe dry eye syndrome.","oneSentence":"Prosicca sine is a mucin-based bioadhesive formulation designed to provide sustained lubrication and protection to the ocular surface in dry eye disease.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:36:44.681Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe dry eye syndrome / keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT02533154","phase":"PHASE4","title":"Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2015-07-27","conditions":"Dry Eye Syndromes","enrollment":40}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"CEREBRAL HAEMORRHAGE"},{"count":1,"reaction":"DRUG INTERACTION"},{"count":1,"reaction":"DYSPHAGIA"},{"count":1,"reaction":"PNEUMONIA"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Prosicca sine","genericName":"Prosicca sine","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prosicca sine is a mucin-based bioadhesive formulation designed to provide sustained lubrication and protection to the ocular surface in dry eye disease. Used for Severe dry eye syndrome / keratoconjunctivitis sicca.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}