{"id":"propylparaben","rwe":[{"pmid":"41893479","year":"2026","title":"Associations of Exposure to Parabens During Pregnancy with Behavior in Early Childhood.","finding":"","journal":"Toxics","studyType":"Clinical Study"},{"pmid":"41893471","year":"2026","title":"Acute and Chronic Toxicity of Propylparaben in the Freshwater Snail Biomphalaria glabrata: Effects on Survival, Growth, Reproduction, and Histopathology.","finding":"","journal":"Toxics","studyType":"Clinical Study"},{"pmid":"41870785","year":"2026","title":"Investigating changes in serum metabolome and urinary endocrine disrupting chemicals in cats with hyperthyroidism.","finding":"","journal":"Veterinary research communications","studyType":"Clinical Study"},{"pmid":"41832856","year":"2026","title":"Low-viscosity ternary NADES for green extraction and UHPLC-DAD determination of potential endocrine-disrupting contaminants in wastewater.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"41735231","year":"2026","title":"Temporal (2012-2021), Age, and Sex Trends in Exposure to Bisphenols, Antimicrobials, and Parabens in the Australian General Population.","finding":"","journal":"Environmental science & technology","studyType":"Clinical Study"}],"tags":[{"label":"Standardized Chemical Allergen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Concentrate","category":"form"},{"label":"Cream","category":"form"},{"label":"Active","category":"status"},{"label":"Pharmaceutic Aids","category":"pharmacology"},{"label":"Preservatives, Pharmaceutical","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nipasol","offLabel":[],"synonyms":["propylparaben","nipasol","propyl butex","propyl 4-hydroxybenzoate","propyl hydroxybenzoate","propylparabenum"],"timeline":[],"approvals":[],"brandName":"Nipasol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Standardized Chemical Allergen","explanation":"Imagine your immune system as a security guard. Nipasol is like a fake intruder that the guard recognizes and responds to, triggering an allergic reaction. This reaction is a normal response to a perceived threat, but in this case, it's a controlled response for diagnostic purposes.","oneSentence":"Nipasol works by binding to and activating immune cells, triggering an allergic response.","technicalDetail":"Propylparaben acts as a hapten, a small molecule that binds to and modifies the structure of proteins, making them recognizable to the immune system and triggering an immune response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2307","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=propylparaben","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=propylparaben","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:30:42.974844","biosimilars":[],"competitors":[],"genericName":"propylparaben","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07053774","phase":"PHASE2","title":"Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2025-11-05","conditions":["Pain, Acute"],"enrollment":24,"completionDate":"2026-06-20"},{"nctId":"NCT06750653","phase":"PHASE4","title":"Skin Barrier Function and Inflammation in Aging: The BIA Study","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-02-06","conditions":["Inflammation","Skin Inflammation","Aging"],"enrollment":32,"completionDate":"2026-04-15"},{"nctId":"NCT05079763","phase":"NA","title":"Bacterial Cellulose-monolaurin Hydrogel for Acute Radiation Dermatitis","status":"RECRUITING","sponsor":"University of the Philippines","startDate":"2021-09-01","conditions":["Acute Radiation Dermatitis"],"enrollment":54,"completionDate":"2028-12-31"},{"nctId":"NCT05249556","phase":"PHASE3","title":"Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Years Old","status":"NOT_YET_RECRUITING","sponsor":"Immedica Pharma AB","startDate":"2026-06","conditions":["CDKL5 Deficiency Disorder"],"enrollment":20,"completionDate":"2028-09"},{"nctId":"NCT06984484","phase":"NA","title":"Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease","status":"RECRUITING","sponsor":"Devintec Sagl","startDate":"2025-07-02","conditions":["Gastroesophageal Reflux Disease (GERD)"],"enrollment":208,"completionDate":"2026-06"},{"nctId":"NCT06980961","phase":"NA","title":"Short and Ultra-short-pulse ND: YAG 1064nm Lasers (Omer Smart and Omer Premium) for Stasis Dermatitis","status":"RECRUITING","sponsor":"Science Valley Research Institute","startDate":"2025-05-20","conditions":["Stasis Dermatitis"],"enrollment":20,"completionDate":"2026-12-01"},{"nctId":"NCT06268184","phase":"NA","title":"Effect of Omega 3 on Oxidative Stress and Nutritional Status of Children on Regular Dialysis","status":"RECRUITING","sponsor":"Tanta University","startDate":"2021-10-04","conditions":["Oxidative Stress"],"enrollment":45,"completionDate":"2024-08-15"},{"nctId":"NCT06414161","phase":"NA","title":"Management of Radiotherapy-related Xerostomia With Green Tea and Peppermint","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":["Radiation-induced Xerostomia"],"enrollment":40,"completionDate":"2024-12"},{"nctId":"NCT05886673","phase":"NA","title":"Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.","status":"UNKNOWN","sponsor":"Antonio J. 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