{"id":"propofol-rocuronium-fentanyl-inhalational","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypotension"},{"rate":"variable","effect":"Respiratory depression"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"10-20","effect":"Injection site pain (propofol)"},{"rate":"20-30","effect":"Postoperative nausea and vomiting"},{"rate":"variable","effect":"Apnea"},{"rate":"variable","effect":"Muscle rigidity"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol is an intravenous hypnotic agent that depresses the central nervous system to induce and maintain anesthesia. Rocuronium is a neuromuscular blocking agent that paralyzes skeletal muscles by blocking acetylcholine receptors at the neuromuscular junction. Fentanyl is an opioid analgesic that provides intraoperative analgesia, while inhalational agents (likely sevoflurane or isoflurane) maintain anesthetic depth throughout the procedure.","oneSentence":"This is a combination anesthetic regimen that induces unconsciousness, provides muscle paralysis, and delivers pain relief for surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:25.109Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia for surgical procedures"}]},"trialDetails":[{"nctId":"NCT07370779","phase":"NA","title":"The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2021-01-01","conditions":"Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient","enrollment":30},{"nctId":"NCT07363681","phase":"NA","title":"Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia","status":"RECRUITING","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2024-10-01","conditions":"Ureterorenoscopic Lithotripsy, Transurethral Resection of the Bladder, Percutaneous Nephrolithotomy","enrollment":150},{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT05343260","phase":"NA","title":"Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2015-04-01","conditions":"Aged, Neoplasms, Surgical Procedure, Operative","enrollment":1228},{"nctId":"NCT07092046","phase":"NA","title":"Minimal Flow Anesthesia and Infection Risk","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2025-07-01","conditions":"Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia","enrollment":140},{"nctId":"NCT03434678","phase":"PHASE3","title":"Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2018-01-30","conditions":"Pancreatic Cancer","enrollment":133},{"nctId":"NCT06953193","phase":"NA","title":"Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia","status":"RECRUITING","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2025-04-07","conditions":"Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy","enrollment":206},{"nctId":"NCT04962672","phase":"NA","title":"Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2022-01-01","conditions":"Anesthesia, Brain Cancer, Survival","enrollment":40},{"nctId":"NCT05596227","phase":"NA","title":"Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane Block","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-10-20","conditions":"Analgesia, Lumbar Spine Disease","enrollment":180},{"nctId":"NCT06045559","phase":"","title":"Effects of Anesthetics on High-Dose Rocuronium","status":"RECRUITING","sponsor":"Mustafa Kemal University","startDate":"2023-10-02","conditions":"Neuromuscular Blockade, Anesthetic Agents","enrollment":75},{"nctId":"NCT06269328","phase":"NA","title":"Measuring Sleep Quality In Patients That Posterior Spinal Instrumentatıon Plannıng","status":"COMPLETED","sponsor":"Uludag University","startDate":"2022-07-01","conditions":"Sleep Disorder, Sleep, Inadequate, Total ıntravenous Anesthesia","enrollment":39},{"nctId":"NCT05639686","phase":"NA","title":"TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality","status":"UNKNOWN","sponsor":"Our Lady of the Lake Hospital","startDate":"2023-01-01","conditions":"Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp","enrollment":100},{"nctId":"NCT05543109","phase":"NA","title":"Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2022-09-29","conditions":"Pain, Postoperative, Hip Dysplasia","enrollment":85},{"nctId":"NCT02660411","phase":"NA","title":"Impact of Anesthesia Maintenance Methods on Long-term Survival","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2015-04-01","conditions":"Aged, Neoplasms, Surgical Procedure, Operative","enrollment":1228},{"nctId":"NCT04802122","phase":"PHASE4","title":"Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2021-05-24","conditions":"Anesthesia Intubation Complication, Cardiovascular Complication, Intubation","enrollment":60},{"nctId":"NCT01661907","phase":"NA","title":"Anesthesia-analgesia Methods and Postoperative Delirium","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2011-11-21","conditions":"Elderly, Epidural Anesthesia, General Anesthesia","enrollment":1800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Propofol+ Rocuronium+ Fentanyl + Inhalational","genericName":"Propofol+ Rocuronium+ Fentanyl + Inhalational","companyName":"Memorial Sloan Kettering Cancer Center","companyId":"memorial-sloan-kettering-cancer-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination anesthetic regimen that induces unconsciousness, provides muscle paralysis, and delivers pain relief for surgical procedures. Used for Induction and maintenance of general anesthesia for surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}