{"id":"propofol-rocuronium-caffeine-tylenol-bupivacaine","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypotension"},{"rate":"variable","effect":"Respiratory depression"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"10-50","effect":"Injection site pain (propofol)"},{"rate":"20-30","effect":"Postoperative nausea and vomiting"},{"rate":"variable","effect":"Muscle rigidity"},{"rate":"<1","effect":"Anaphylaxis (rare)"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol enhances GABAergic inhibitory neurotransmission to produce sedation and anesthesia. Rocuronium competitively blocks acetylcholine at the neuromuscular junction to produce paralysis. Caffeine antagonizes adenosine receptors to promote wakefulness. Acetaminophen reduces pain and fever through unclear mechanisms involving COX inhibition and TRPV1 modulation. Bupivacaine blocks voltage-gated sodium channels in nerve fibers to produce local anesthesia.","oneSentence":"This is a combination of five distinct drugs with different mechanisms: propofol (GABA agonist for sedation), rocuronium (neuromuscular blocker), caffeine (adenosine antagonist), acetaminophen (analgesic/antipyretic), and bupivacaine (local anesthetic).","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:03.392Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance (propofol, rocuronium, bupivacaine)"},{"name":"Postoperative pain management (acetaminophen, bupivacaine)"},{"name":"Postoperative sedation reversal (caffeine)"}]},"trialDetails":[{"nctId":"NCT05919732","phase":"PHASE4","title":"Awake Caudal Catheter vs General Anesthesia","status":"COMPLETED","sponsor":"Nemours Children's Clinic","startDate":"2016-03-08","conditions":"Inguinal Hernia","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Propofol, rocuronium, caffeine, Tylenol, bupivacaine","genericName":"Propofol, rocuronium, caffeine, Tylenol, bupivacaine","companyName":"Nemours Children's Clinic","companyId":"nemours-children-s-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of five distinct drugs with different mechanisms: propofol (GABA agonist for sedation), rocuronium (neuromuscular blocker), caffeine (adenosine antagonist), acetaminophen (analgesic/antipyretic), and bupivacaine (local anesthetic). Used for Anesthesia induction and maintenance (propofol, rocuronium, bupivacaine), Postoperative pain management (acetaminophen, bupivacaine), Postoperative sedation reversal (caffeine).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}