{"id":"propofol-postconditioning","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol, a commonly used intravenous anesthetic, has been studied as a postconditioning agent to mitigate ischemia-reperfusion injury in cardiac tissue. When administered at the onset of reperfusion after a period of ischemia, propofol appears to activate cardioprotective signaling pathways, reduce oxidative stress, and inhibit apoptosis, thereby preserving myocardial viability and function. This approach leverages propofol's antioxidant and anti-inflammatory properties to enhance recovery in acute coronary syndromes and cardiac surgery.","oneSentence":"Propofol postconditioning is a cardioprotective strategy in which propofol is administered during the early reperfusion phase following ischemia to reduce myocardial injury and improve cardiac function.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:03:06.812Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myocardial ischemia-reperfusion injury during acute coronary syndrome"},{"name":"Cardioprotection during cardiac surgery with cardiopulmonary bypass"}]},"trialDetails":[{"nctId":"NCT04950205","phase":"EARLY_PHASE1","title":"Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2021-06-01","conditions":"Postoperative Cognitive Dysfunction, Sevoflurane, Carotid Artery Intima Stripped","enrollment":140},{"nctId":"NCT02946437","phase":"PHASE2","title":"Sevoflurane in Subarachnoidal Haemorrhage","status":"WITHDRAWN","sponsor":"University of Zurich","startDate":"2015-11-01","conditions":"Subarachnoid Haemorrhage (SAH)","enrollment":""},{"nctId":"NCT02691416","phase":"PHASE4","title":"Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function","status":"COMPLETED","sponsor":"The Third Central Clinical College of Tianjin Medical University","startDate":"2014-07","conditions":"Cerebral Arterial Aneurysm","enrollment":60},{"nctId":"NCT02378168","phase":"","title":"6-month Follow up After Sevoflurane Postconditioning","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2014-04","conditions":"Heart Surgical Procedures","enrollment":108},{"nctId":"NCT00924222","phase":"NA","title":"Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2007-10","conditions":"Cardiac On-pump Surgery","enrollment":120},{"nctId":"NCT00518908","phase":"NA","title":"Organ Protection With Sevoflurane Postconditioning","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2008-01","conditions":"Hepatectomy","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"propofol postconditioning","genericName":"propofol postconditioning","companyName":"The Third Central Clinical College of Tianjin Medical University","companyId":"the-third-central-clinical-college-of-tianjin-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propofol postconditioning is a cardioprotective strategy in which propofol is administered during the early reperfusion phase following ischemia to reduce myocardial injury and improve cardiac function. Used for Myocardial ischemia-reperfusion injury during acute coronary syndrome, Cardioprotection during cardiac surgery with cardiopulmonary bypass.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}