{"id":"propofol-drug","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Respiratory depression"},{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Bradycardia"},{"rate":"5-10%","effect":"Nausea and vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Propofol works by enhancing the inhibitory neurotransmission mediated by GABA (gamma-aminobutyric acid), a major inhibitory neurotransmitter in the brain. This results in a decrease in neuronal excitability, leading to sedation, hypnosis, and amnesia.","oneSentence":"Propofol is a short-acting sedative-hypnotic agent that acts on the central nervous system to induce and maintain anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:58.687Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia"},{"name":"Sedation for mechanical ventilation"},{"name":"Sedation for diagnostic or surgical procedures"}]},"trialDetails":[{"nctId":"NCT07496593","phase":"PHASE4","title":"Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-12-01","conditions":"Diabete Mellitus, VATS, TIVA","enrollment":60},{"nctId":"NCT07191652","phase":"","title":"The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index","status":"RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-03-25","conditions":"Ear Throat Nose Surgery, Delirium - Postoperative, Pain Postoperative","enrollment":120},{"nctId":"NCT07211828","phase":"NA","title":"EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives","status":"RECRUITING","sponsor":"Chi Kwan Fung","startDate":"2025-10-10","conditions":"Sedation and Analgesia, Cholangiopancreatography, Endoscopic Retrograde, Anesthesia, General","enrollment":20},{"nctId":"NCT06867068","phase":"PHASE1","title":"Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery","status":"COMPLETED","sponsor":"Albert Einstein College of Medicine","startDate":"2016-10-04","conditions":"Anesthesia, Tooth Extraction","enrollment":73},{"nctId":"NCT05514405","phase":"NA","title":"Effect of Remimazolam and Propofol on Postoperative Delirium","status":"RECRUITING","sponsor":"Inje University","startDate":"2022-08-01","conditions":"Hip Fractures, Knee Osteoarthritis, Femur Fracture","enrollment":82},{"nctId":"NCT07251101","phase":"NA","title":"Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Ilsan Cha hospital","startDate":"2026-05-02","conditions":"Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery","enrollment":58},{"nctId":"NCT07445672","phase":"NA","title":"Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2026-03-01","conditions":"Patient Cataract","enrollment":40},{"nctId":"NCT07362173","phase":"PHASE4","title":"Actualities in Procedural Sedation: Remimazolam","status":"ACTIVE_NOT_RECRUITING","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2025-03-01","conditions":"ASA Class III/IV Patients, COPD III/IV, Age 65 and Older","enrollment":200},{"nctId":"NCT07491991","phase":"PHASE4","title":"Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery","status":"COMPLETED","sponsor":"Qianfoshan Hospital","startDate":"2025-03-02","conditions":"Postoperative Pain, NEBULIZATION, Thyroid Surgery","enrollment":96},{"nctId":"NCT03783494","phase":"PHASE4","title":"Target-controlled Infusion With Propofol in the Emergency Department : a Prospective Study on 45 Adult Patients","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2019-05-09","conditions":"Joint Dislocation, Limb Fracture","enrollment":45},{"nctId":"NCT07410702","phase":"","title":"Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia","status":"RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2026-02-10","conditions":"Altered State of Consciousness, General Anesthetics","enrollment":250},{"nctId":"NCT05327296","phase":"PHASE3","title":"Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)","status":"COMPLETED","sponsor":"Sedana Medical","startDate":"2022-06-30","conditions":"Sedation","enrollment":282},{"nctId":"NCT05312385","phase":"PHASE3","title":"Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)","status":"COMPLETED","sponsor":"Sedana Medical","startDate":"2022-04-28","conditions":"Sedation","enrollment":277},{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT04992572","phase":"EARLY_PHASE1","title":"Study Comparing Local/ MAC Anesthesia in Lumbar Decompression","status":"RECRUITING","sponsor":"Stanford University","startDate":"2021-12-01","conditions":"Lumbar Spinal Stenosis","enrollment":100},{"nctId":"NCT07485517","phase":"NA","title":"Deep Versus Moderate Neuromuscular Blocking","status":"RECRUITING","sponsor":"Menoufia University","startDate":"2026-02-01","conditions":"Change in Serum Levels of the Estimated Inflammatory Cytokines, Total Dose of IO Fentanyl, PO Morphine","enrollment":88},{"nctId":"NCT07479719","phase":"PHASE4","title":"Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2026-04","conditions":"Elderly, Surgery, Depth of Anesthesia","enrollment":200},{"nctId":"NCT07479550","phase":"PHASE2","title":"Anesthesia-Masked Psilocybin Therapy for Major Depression","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-07","conditions":"Major Depression","enrollment":10},{"nctId":"NCT07463911","phase":"","title":"Treatment Response In ECT Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nurdan Sağbaş","startDate":"2025-05-20","conditions":"Major Depression, Bipolar Affective Disorder, Bipolar Depression Depressed Phase","enrollment":65},{"nctId":"NCT07001267","phase":"NA","title":"Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2025-06-04","conditions":"Acute Ischemic Stroke Patients","enrollment":120},{"nctId":"NCT06353516","phase":"NA","title":"The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients","status":"COMPLETED","sponsor":"Chung-Ang University Gwangmyeong Hospital","startDate":"2024-02-14","conditions":"Postoperative Cognitive Dysfunction","enrollment":154},{"nctId":"NCT07462195","phase":"PHASE4","title":"Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery","status":"NOT_YET_RECRUITING","sponsor":"Bach Mai Hospital","startDate":"2026-03","conditions":"Thyroid Diseases","enrollment":100},{"nctId":"NCT07197567","phase":"","title":"Equivalent MAC in General Anesthesia","status":"COMPLETED","sponsor":"Sakarya University","startDate":"2025-11-01","conditions":"General Anesthesia, Intraoperative Monitoring, Anesthetic Depth","enrollment":60},{"nctId":"NCT07161518","phase":"PHASE4","title":"Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation","status":"ENROLLING_BY_INVITATION","sponsor":"Stanford University","startDate":"2025-09-01","conditions":"Healthy Participants","enrollment":10},{"nctId":"NCT07460050","phase":"NA","title":"Comparison of Two Sedative Agents in Terms of Controlled Hypotension","status":"NOT_YET_RECRUITING","sponsor":"Hayatabad Medical Complex","startDate":"2026-03-01","conditions":"Controlled Hypotension for Nasal Surgeries","enrollment":136},{"nctId":"NCT05907811","phase":"NA","title":"General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2023-06-05","conditions":"Thoracal Epidural Block","enrollment":60},{"nctId":"NCT07333859","phase":"PHASE4","title":"Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP","status":"RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2026-02-11","conditions":"Duodenal Spasm, ERCP, Sedation","enrollment":120},{"nctId":"NCT07336628","phase":"NA","title":"Propofol vs Remifentanil for Sedation in Gastroscopy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fatih Sultan Mehmet Training and Research Hospital","startDate":"2025-11-01","conditions":"Conscious Sedation, Procedural Sedation","enrollment":80},{"nctId":"NCT06950515","phase":"NA","title":"General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound","status":"RECRUITING","sponsor":"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval","startDate":"2025-09-25","conditions":"Lung Cancers, Peripheral Pulmonary Nodules","enrollment":306},{"nctId":"NCT07456111","phase":"PHASE4","title":"A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy","status":"RECRUITING","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2025-01-01","conditions":"Colonic Polyp, Sedation Complication","enrollment":90},{"nctId":"NCT06772727","phase":"PHASE4","title":"Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-02-01","conditions":"Post-induction Hypotension, Lidocaine, Opioid","enrollment":149},{"nctId":"NCT07269808","phase":"PHASE3","title":"Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-03-03","conditions":"Anesthesia, Sedation, Endoscopy","enrollment":100},{"nctId":"NCT07110428","phase":"NA","title":"Supraglottic Jet Oxygenation Ventilation During Hysteroscopic Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Peking University Shenzhen Hospital","startDate":"2025-07-03","conditions":"Hysteroscopic Surgery","enrollment":100},{"nctId":"NCT07000526","phase":"PHASE4","title":"Inhaled Sedation in Critically Ill Patients","status":"RECRUITING","sponsor":"Instituto de Investigación Hospital Universitario La Paz","startDate":"2025-12-15","conditions":"Sedation, Airway Extubation","enrollment":620},{"nctId":"NCT07435402","phase":"NA","title":"Reduction of Muscle Catabolism Through Brain Activation in Burn Patients","status":"NOT_YET_RECRUITING","sponsor":"Charles University, Czech Republic","startDate":"2026-05-01","conditions":"Burns - Multiple, Critical Illness, Muscle Weakness","enrollment":30},{"nctId":"NCT07120230","phase":"NA","title":"Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Guangzhou Medical University","startDate":"2025-08-03","conditions":"Lung Transplant Recipient","enrollment":30},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07433231","phase":"NA","title":"Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients","status":"COMPLETED","sponsor":"Ayfer Kaya Gök","startDate":"2023-11-01","conditions":"Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy","enrollment":100},{"nctId":"NCT06784479","phase":"PHASE4","title":"Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dan Liu","startDate":"2025-03-01","conditions":"Sedative Effect During Drug-induced Sleep Endoscopy, Obstructive Sleep Apnea (OSA)","enrollment":174},{"nctId":"NCT07395596","phase":"PHASE4","title":"Remimazolam for Bronchoscopy in High-Risk Patients","status":"RECRUITING","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2026-02-09","conditions":"Pulmonary Infection, Pulmonary Nodule, Phthisis","enrollment":360},{"nctId":"NCT06349057","phase":"PHASE4","title":"The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-01-01","conditions":"Postoperative Recovery, Length of Hospital Stay, Postoperative Complications","enrollment":120},{"nctId":"NCT06180876","phase":"NA","title":"Effect of Remimazolam on Postoperative Delirium","status":"COMPLETED","sponsor":"Zhihong LU","startDate":"2022-07-25","conditions":"General Anesthetic Drug Adverse Reaction","enrollment":264},{"nctId":"NCT07404306","phase":"PHASE1","title":"Part 1: Dose-Finding of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users","status":"COMPLETED","sponsor":"Haisco-USA Pharmaceuticals, Inc.","startDate":"2022-08-16","conditions":"General Anesthesia","enrollment":43},{"nctId":"NCT03556696","phase":"NA","title":"Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2018-06-27","conditions":"Nociceptive Pain, Surgical Procedure, Unspecified","enrollment":52},{"nctId":"NCT07423676","phase":"","title":"Comparison Between Two Drugs in Sedation of Upper GI Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2026-03-01","conditions":"Sedation During GI Endoscopy","enrollment":52},{"nctId":"NCT07422558","phase":"NA","title":"Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain","status":"NOT_YET_RECRUITING","sponsor":"Hayatabad Medical Complex","startDate":"2026-03-01","conditions":"Procedural Pain","enrollment":92},{"nctId":"NCT07211399","phase":"EARLY_PHASE1","title":"Transition From Acute to Chronic Opioid Use and Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. Chelly","startDate":"2026-03-01","conditions":"Opioid Use Disorder","enrollment":700},{"nctId":"NCT07222007","phase":"","title":"Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients","status":"RECRUITING","sponsor":"Zeliha Alicikus","startDate":"2026-02-18","conditions":"Critically Ill, Intubation Complication, Oxygenation","enrollment":4},{"nctId":"NCT07036419","phase":"PHASE2, PHASE3","title":"A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients","status":"RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-07-10","conditions":"Operative Sedation of Pediatric, Operative Sedation of Adolescent Patients","enrollment":240},{"nctId":"NCT07414706","phase":"PHASE3","title":"Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-03","conditions":"Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery","enrollment":182},{"nctId":"NCT07409935","phase":"PHASE4","title":"A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-04-01","conditions":"Patients Undergoing Rigid Bronchoscopy","enrollment":50},{"nctId":"NCT07401914","phase":"","title":"Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Giresun University","startDate":"2026-02-02","conditions":"Procedural Sedation, Gastrointestinal Endoscopy","enrollment":90},{"nctId":"NCT05509192","phase":"PHASE4","title":"Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2022-08-17","conditions":"Anesthesia","enrollment":154},{"nctId":"NCT05508971","phase":"NA","title":"Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2023-08-02","conditions":"Obstructive Sleep Apnea, Down Syndrome","enrollment":303},{"nctId":"NCT07384169","phase":"","title":"Cognitive Function in Geriatric Colonoscopy Patients","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2023-08-01","conditions":"Cognition, Sedation, Geriatric Anesthesia","enrollment":164},{"nctId":"NCT02851433","phase":"PHASE4","title":"Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2015-10-14","conditions":"Cardiac Surgery","enrollment":82},{"nctId":"NCT06034873","phase":"PHASE2","title":"Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation","status":"COMPLETED","sponsor":"Benha University","startDate":"2023-11-15","conditions":"Perioperative Pain","enrollment":42},{"nctId":"NCT07268872","phase":"NA","title":"Dynamic Effects of Different Anesthetic Agents on the Immune Function of Healthy Volunteers","status":"ENROLLING_BY_INVITATION","sponsor":"Henan Provincial People's Hospital","startDate":"2025-11-21","conditions":"Immune System","enrollment":80},{"nctId":"NCT03864016","phase":"NA","title":"Ability of Pupillometry to Reduce Sufentanil Consumption in Planned Cardiac Surgery: Randomized, Controlled, Single-center Clinical Superiority Trial","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2019-03-20","conditions":"Patients Undergoing Cardiac Surgery, Patients With Coronary Artery Bypass Surgery With CEC","enrollment":50},{"nctId":"NCT06467279","phase":"","title":"Comparing Inhalation and Total Intravenous Anesthesia Methods","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2022-08-15","conditions":"Children, Hernia, Inguinal","enrollment":60},{"nctId":"NCT07378878","phase":"NA","title":"COMPARISON OF SEVOFLURANE AND PROPOFOL ADMINISTRATION ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN SPINAL SURGERY USING THE MINI-MENTAL STATE EXAMINATION (MMSE)","status":"COMPLETED","sponsor":"Universitas Sumatera Utara","startDate":"2025-02-01","conditions":"Condition / Focus: Postoperative Cognitive Dysfunction (POCD) Following Spinal Surgery","enrollment":20},{"nctId":"NCT04871308","phase":"NA","title":"Dexmedetomidine and Myocardial Protection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-07-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass","enrollment":224},{"nctId":"NCT07378241","phase":"","title":"Effects of Patients' Hormone Levels on Sedoanalgesia","status":"NOT_YET_RECRUITING","sponsor":"Izmir City Hospital","startDate":"2026-01-30","conditions":"Consumption of Anaesthetic Agents, Sedoanalgesia","enrollment":100},{"nctId":"NCT07376577","phase":"NA","title":"Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xinxiang Medical College","startDate":"2026-01-01","conditions":"Anesthesia, Sedation, ERCP","enrollment":141},{"nctId":"NCT05303987","phase":"PHASE2","title":"Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea","status":"RECRUITING","sponsor":"Erin Kirkham","startDate":"2022-10-05","conditions":"Obstructive Sleep Apnea","enrollment":90},{"nctId":"NCT07377123","phase":"NA","title":"Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation","status":"NOT_YET_RECRUITING","sponsor":"Jianxing He","startDate":"2026-01-12","conditions":"Kidney Transplantation, CKD (Chronic Kidney Disease) Stage 5D","enrollment":60},{"nctId":"NCT07028593","phase":"PHASE4","title":"Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2025-07-31","conditions":"Myocardial Injury, Thoracic Diseases, Thoracoscopic Surgery","enrollment":1058},{"nctId":"NCT07304206","phase":"NA","title":"The Effects of Three Different Anesthetic Methods on Postoperative Agitation","status":"ENROLLING_BY_INVITATION","sponsor":"Inonu University","startDate":"2025-12-25","conditions":"Emergence Agitation, Septoplasty Surgeries","enrollment":3},{"nctId":"NCT07369128","phase":"PHASE4","title":"Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging","status":"NOT_YET_RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2026-02","conditions":"MRI Sedation, Pediatric Sedation, Propofol Dosage","enrollment":105},{"nctId":"NCT07370779","phase":"NA","title":"The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2021-01-01","conditions":"Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient","enrollment":30},{"nctId":"NCT07363681","phase":"NA","title":"Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia","status":"RECRUITING","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2024-10-01","conditions":"Ureterorenoscopic Lithotripsy, Transurethral Resection of the Bladder, Percutaneous Nephrolithotomy","enrollment":150},{"nctId":"NCT07359508","phase":"PHASE4","title":"Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter","status":"COMPLETED","sponsor":"All India Institute of Medical Sciences","startDate":"2024-01-10","conditions":"Propofol Target-controlled Infusion, Desflurane, Optic Nerve Sheath Diameter","enrollment":146},{"nctId":"NCT04760912","phase":"PHASE4","title":"General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery","status":"COMPLETED","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2020-04-01","conditions":"Rocuronium, Muscle Weakness, General Anaesthesia","enrollment":60},{"nctId":"NCT07351474","phase":"NA","title":"Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2026-01-01","conditions":"Gastric Cancer, Postoperative Delirium","enrollment":170},{"nctId":"NCT05358535","phase":"PHASE3","title":"Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2022-09-19","conditions":"Anesthesia, Propofol Adverse Reaction, Etomidate Adverse Reaction","enrollment":200},{"nctId":"NCT06310785","phase":"NA","title":"Esketamine Anesthesia in Thoracic Surgery","status":"COMPLETED","sponsor":"Hui Xu","startDate":"2024-02-04","conditions":"General Anesthesia, Thoracic Surgery","enrollment":84},{"nctId":"NCT07347496","phase":"PHASE4","title":"A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xinxiang Medical College","startDate":"2026-03-01","conditions":"Thoracic Surgery, Anesthesia, Non-intubated Anesthesia","enrollment":50},{"nctId":"NCT07348159","phase":"NA","title":"Effect of Nalbuphine on Hemodynamic Response During Laryngoscopy and Intubation","status":"COMPLETED","sponsor":"Dr. Waseem Ullah","startDate":"2024-03-01","conditions":"Hemodynamic Response to Laryngoscopy and Orotracheal Intubation","enrollment":107},{"nctId":"NCT04281017","phase":"PHASE4","title":"Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients","status":"RECRUITING","sponsor":"University of Florida","startDate":"2020-11-10","conditions":"Intraocular Pressure, Oncology","enrollment":40},{"nctId":"NCT07348614","phase":"PHASE4","title":"Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-03","conditions":"Knee Stiffness After Total Knee Arthroplasty","enrollment":128},{"nctId":"NCT07271459","phase":"NA","title":"Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-02","conditions":"Anesthesia","enrollment":40},{"nctId":"NCT06707818","phase":"","title":"Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery","status":"COMPLETED","sponsor":"V.K.V. American Hospital, Istanbul","startDate":"2024-04-15","conditions":"Postoperative Pain, Psychological Factors, Breast Surgery","enrollment":52},{"nctId":"NCT05881291","phase":"PHASE4","title":"Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2023-06-29","conditions":"Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia","enrollment":124},{"nctId":"NCT07338578","phase":"","title":"A Study Comparing Sevoflurane and Propofol in Patients Undergoing Endobronchial Ultrasound Guided Needle Aspiration","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2023-09-01","conditions":"Hemodynamic Stability, Pulmonary Diseases or Conditions, Complication of Anesthesia","enrollment":102},{"nctId":"NCT07335536","phase":"NA","title":"The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval: A Multicenter Randomized Controlled Trial.","status":"RECRUITING","sponsor":"Diansan Su","startDate":"2025-10-20","conditions":"Hypoxia, Infertility, Infertility Assisted Reproductive Technology","enrollment":400},{"nctId":"NCT07334132","phase":"PHASE4","title":"General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Region Örebro County","startDate":"2026-04-01","conditions":"Osteo Arthritis Knee and Hip, Osteo Arthritis, Inflammatory Joint Disease (IJD)","enrollment":600},{"nctId":"NCT06222294","phase":"PHASE3","title":"A Study of Remimazolam Tosilate for Sedation in the ICU","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2024-03-12","conditions":"Sedation in the ICU","enrollment":214},{"nctId":"NCT07326332","phase":"NA","title":"Effect of Dexmedetomidine on Tear Production in Angioplasty Patients","status":"NOT_YET_RECRUITING","sponsor":"Benha University","startDate":"2026-01-01","conditions":"Tear Film Alteration","enrollment":52},{"nctId":"NCT07325669","phase":"NA","title":"Comparison of the Effects of Total Intravenous Anaesthesia With Target-Controlled Infusion (TCI) and Inhalation Anaesthesia on Airway Complications During Extubation and in the Early Postoperative Period in Thyroidectomy Surgery","status":"NOT_YET_RECRUITING","sponsor":"dilara gocmen","startDate":"2026-01-01","conditions":"Throid Surgery, Airway Complication of Anaesthesia, Coughing Responses at Tracheal Extubation","enrollment":100},{"nctId":"NCT03404180","phase":"PHASE4","title":"Peripheral Nerve Blocks for Above-the-knee Amputations","status":"COMPLETED","sponsor":"University of Florida","startDate":"2018-02-09","conditions":"Peripheral Vascular Diseases, Hyperglycaemia (Diabetic), Hypertension","enrollment":30},{"nctId":"NCT06575530","phase":"PHASE4","title":"Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients","status":"RECRUITING","sponsor":"Beijing Shijitan Hospital, Capital Medical University","startDate":"2025-01-20","conditions":"Effect of Drug, Adverse Drug Event, Mechanical Ventilation Complication","enrollment":306},{"nctId":"NCT07247968","phase":"EARLY_PHASE1","title":"Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study","status":"RECRUITING","sponsor":"Min Su","startDate":"2025-11-25","conditions":"Esketamine, ECT, Depression","enrollment":220},{"nctId":"NCT03756961","phase":"NA","title":"Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery","status":"RECRUITING","sponsor":"Göteborg University","startDate":"2019-05-01","conditions":"Obesity, Pain, Postoperative","enrollment":220},{"nctId":"NCT04706026","phase":"NA","title":"A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2024-10-23","conditions":"Inguinal Hernia, Anesthesia, Local","enrollment":80},{"nctId":"NCT06897696","phase":"PHASE4","title":"Effect of Dexmedetomidine and Total Intravenous Anesthesia on Endothelial Damage-Related Biomarkers","status":"COMPLETED","sponsor":"Firat University","startDate":"2025-04-10","conditions":"Endothelial Damage, Dexmedetomidine, Syndecan 1","enrollment":90},{"nctId":"NCT06788743","phase":"NA","title":"Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial","status":"RECRUITING","sponsor":"Xijing Hospital","startDate":"2025-06-01","conditions":"Postoperative Delirium (POD), Diabetes","enrollment":450},{"nctId":"NCT07271472","phase":"NA","title":"Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS","status":"RECRUITING","sponsor":"Ataturk University","startDate":"2025-12-01","conditions":"VATS, Video Assisted Thoracoscopic Surgery","enrollment":60},{"nctId":"NCT07187765","phase":"NA","title":"Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2025-09-22","conditions":"Hypoxemia During Surgery, Gastrointestinal Endoscopy","enrollment":508},{"nctId":"NCT02527083","phase":"PHASE4","title":"Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain","status":"COMPLETED","sponsor":"VA Pittsburgh Healthcare System","startDate":"2015-01","conditions":"Acute Pain, Chronic Pain, Hernia","enrollment":10},{"nctId":"NCT07303985","phase":"PHASE4","title":"The Effects of Remimazolam on Cerebral Blood Flow Following General Anesthesia Induction","status":"NOT_YET_RECRUITING","sponsor":"Jun Zhang","startDate":"2025-12-31","conditions":"Cerebral Blood Flow","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"propofol (drug)","genericName":"propofol (drug)","companyName":"B. Braun Melsungen AG","companyId":"b-braun-melsungen-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propofol is a small molecule that acts as a positive allosteric modulator of the GABA-A receptor, an anion channel. It is used in medical settings for conditions such as sedation, anesthesia, and spinal anesthesia, among others.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}