{"id":"propionibacterium-acnes","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Mild systemic inflammation"}]},"_chembl":{"chemblId":"CHEMBL607042","moleculeType":"Protein","molecularWeight":"1158.23"},"_dailymed":{"setId":"7f62a3d2-703c-4696-9d74-82599ac68f67","title":"PLEO ART A (PROPIONIBACTERIUM ACNES) LIQUID [SANUM KEHLBECK GMBH & CO. KG]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is an immunotherapeutic approach using attenuated or whole Propionibacterium acnes bacteria to trigger both humoral and cell-mediated immune responses against the pathogenic strain. By priming the immune system to recognize and eliminate P. acnes, the vaccine aims to reduce bacterial colonization and associated inflammation in acne lesions. The mechanism leverages the body's adaptive immunity rather than direct antimicrobial action.","oneSentence":"Propionibacterium acnes is a live bacterial vaccine that stimulates immune responses against the causative organism of acne vulgaris.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:02:56.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT05291468","phase":"NA","title":"the PHENOSAR Trial: Use of Antibiotics in Treatment of Sarcoidosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Antonius Hospital","startDate":"2023-02-15","conditions":"Sarcoidosis, Pulmonary, Sarcoidosis Skin","enrollment":40},{"nctId":"NCT05701475","phase":"NA","title":"Cutibacterium Acnes: Triple Prevention in Shoulder Operations","status":"COMPLETED","sponsor":"Clinique Générale dAnnecy","startDate":"2023-01-18","conditions":"Post-Operative Wound Infection, Surgical Site Infection","enrollment":156},{"nctId":"NCT07239349","phase":"NA","title":"Acne Face Wash for Reducing the Contamination Rate in Arthroscopic Rotator Cuff Repair Surgery","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2025-11-18","conditions":"Rotator Cuff Tears of the Shoulder","enrollment":150},{"nctId":"NCT06513182","phase":"NA","title":"Do Wound Protectors Reduce Contamination in Total Shoulder Arthroplasty?","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Utah","startDate":"2024-06-21","conditions":"Cutibacterium Acnes","enrollment":100},{"nctId":"NCT07085247","phase":"","title":"The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease","status":"RECRUITING","sponsor":"Masaryk University","startDate":"2025-06-01","conditions":"Lumbar Disc Herniation, Lumbar Disc Degeneration, Cutibacterium Acnes","enrollment":400},{"nctId":"NCT02996656","phase":"NA","title":"Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery","status":"RECRUITING","sponsor":"Université de Montréal","startDate":"2016-12","conditions":"Propionibacterium Infection","enrollment":88},{"nctId":"NCT06831422","phase":"NA","title":"Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty","status":"RECRUITING","sponsor":"Henry Ford Health System","startDate":"2025-05-05","conditions":"Shoulder Arthroplasty, Positive C. Acnes Culture","enrollment":150},{"nctId":"NCT04028401","phase":"PHASE3","title":"Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients","status":"RECRUITING","sponsor":"Nantes University Hospital","startDate":"2020-06-19","conditions":"Cutibacterium Acnes Infection","enrollment":110},{"nctId":"NCT05676411","phase":"PHASE4","title":"Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium Acnes","status":"WITHDRAWN","sponsor":"University of Missouri-Columbia","startDate":"2024-06-01","conditions":"Prosthetic-joint Infection","enrollment":""},{"nctId":"NCT03938467","phase":"PHASE4","title":"Irrisept C.Acnes Study","status":"COMPLETED","sponsor":"Orthopaedic Associates of Michigan, PC","startDate":"2021-03-01","conditions":"Rate of Positive Culture Growth for C.Acnes From Specimens Obtained From the Shoulders of Patients Undergoing Primary Shoulder Arthroplasty","enrollment":58},{"nctId":"NCT06379919","phase":"NA","title":"Wound Irrigation Comparative Effectiveness Study","status":"RECRUITING","sponsor":"Orthopaedic Education and Research Institute (dba Hoag Orthopedics)","startDate":"2024-03-20","conditions":"Cutibacterium Acnes Contamination","enrollment":126},{"nctId":"NCT06155513","phase":"NA","title":"Omega-3 Monoglyceride Based Topic Products as Skin Prebiotics for Eczema","status":"RECRUITING","sponsor":"SCF Pharma","startDate":"2023-12-20","conditions":"Eczema","enrollment":16},{"nctId":"NCT06179056","phase":"","title":"Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-03-01","conditions":"Acne Vulgaris","enrollment":48},{"nctId":"NCT05902221","phase":"PHASE3","title":"Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2024-03-30","conditions":"Infections Joint Prosthetic","enrollment":235},{"nctId":"NCT05867108","phase":"","title":"Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study","status":"UNKNOWN","sponsor":"University Hospital, Strasbourg, France","startDate":"2023-06-01","conditions":"Prosthesis Related Infection","enrollment":200},{"nctId":"NCT04112407","phase":"NA","title":"The Effect of Pretreatment for Propionibacterium Acnes on Surgical Site Burden in Shoulder Arthroplasty","status":"COMPLETED","sponsor":"Albany Medical College","startDate":"2019-01-10","conditions":"Shoulder Arthroplasty","enrollment":120},{"nctId":"NCT00031096","phase":"PHASE3","title":"Comparison of Efficacy and Safety of Azelaic Acid 15% Gel With Its Vehicle in Subjects With Mild to Moderate Acne","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2002-01","conditions":"Acne Vulgaris","enrollment":879},{"nctId":"NCT04608916","phase":"NA","title":"Efficacy of Surgical Diathermy in Eradicating Cutibacterium Acnes From Surgical Skin Incision During Shoulder Arthroplasty","status":"COMPLETED","sponsor":"University of Missouri-Columbia","startDate":"2021-06-01","conditions":"Infection, Bacterial","enrollment":64},{"nctId":"NCT05616455","phase":"PHASE4","title":"Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial","status":"COMPLETED","sponsor":"Treviso Regional Hospital","startDate":"2021-10-01","conditions":"Anal Fissure Chronic, Anal Fissure","enrollment":120},{"nctId":"NCT05604469","phase":"","title":"The Role of Skin Microbiota in Hepatic or Renal Pruritus","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2022-10-01","conditions":"Renal Failure, Hepatic Failure, Pruritus","enrollment":60},{"nctId":"NCT05090553","phase":"NA","title":"Protocol for an Analytical Study With Microbiological, Phenotypic, Genotypic and Multiomics Techniques","status":"UNKNOWN","sponsor":"Gaffree & Guinle Universitary Hospital","startDate":"2021-08-01","conditions":"Back Pain, Low, Degenerative Disc Disease","enrollment":120},{"nctId":"NCT00907101","phase":"PHASE4","title":"Evaluate Effectiveness of Epiduo® Gel in Reducing Antibiotic Sensitive & Resistant Strains of Propionibacterium (P)Acnes","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2009-06","conditions":"P Acnes Colonization","enrollment":30},{"nctId":"NCT04300010","phase":"PHASE4","title":"Blue Light Therapy of C. Acnes","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-10-05","conditions":"Acne","enrollment":60},{"nctId":"NCT05355844","phase":"NA","title":"Cutibacterium Acnes in Deep Tissues in Primary Spine and Shoulder Surgery","status":"UNKNOWN","sponsor":"Hospital del Mar","startDate":"2022-05","conditions":"Rotator Cuff Tear Arthropathy, Spine Degeneration","enrollment":200},{"nctId":"NCT03158766","phase":"","title":"Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)","status":"COMPLETED","sponsor":"Hospital Israelita Albert Einstein","startDate":"2017-05-31","conditions":"Infection, Intervertebral Disc Herniation, Propionibacterium Infection","enrollment":108},{"nctId":"NCT01188538","phase":"PHASE4","title":"Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2010-03","conditions":"Acne Vulgaris","enrollment":40},{"nctId":"NCT04712487","phase":"","title":"Low-grade Infections of the Intervertebral Discs","status":"COMPLETED","sponsor":"Kepler University Hospital","startDate":"2018-12-01","conditions":"Disc Degeneration","enrollment":392},{"nctId":"NCT04056598","phase":"","title":"Acne Vulgaris Related Microbiology and Serology","status":"COMPLETED","sponsor":"Sanofi","startDate":"2018-01-18","conditions":"Acne Vulgaris","enrollment":120},{"nctId":"NCT04636242","phase":"PHASE3","title":"Photodynamic Therapy for Cutibacterium Acnes (C. Acnes) Decolonization of the Shoulder Dermis","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2019-08-22","conditions":"C. Acnes, Phototherapy, Postoperative Infection","enrollment":120},{"nctId":"NCT03537664","phase":"NA","title":"Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2017-08-04","conditions":"Periapical Periodontitis, Bacterial Infections","enrollment":45},{"nctId":"NCT04483063","phase":"NA","title":"Can Additional Preoperative Skin Cleaning on Face, Neck and Chest With Chlorhexidine Reduce Cutibacterium Acnes Contamination on Sutures in Arthroscopy Rotator Cuff Repair?","status":"UNKNOWN","sponsor":"National Cheng-Kung University Hospital","startDate":"2020-03-23","conditions":"C. Acnes, Arthroscopic Rotator Cuff Repair","enrollment":90},{"nctId":"NCT03949751","phase":"NA","title":"Acne crème to Reduce Propionibacterium Acnes Load in Primary Shoulder Surgery","status":"COMPLETED","sponsor":"Balgrist University Hospital","startDate":"2018-11-01","conditions":"Shoulder Infections","enrollment":60},{"nctId":"NCT03257202","phase":"PHASE2","title":"Topical Treatment and Prevalence of P. Acnes","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2017-09-11","conditions":"Surgical Site Infection","enrollment":12},{"nctId":"NCT01929057","phase":"","title":"Evaluation of the Role of Propionibacterium Acnes in the Inflammatory Lesions Associated With Acne Vulgaris","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2013-08","conditions":"Acne","enrollment":34},{"nctId":"NCT03057821","phase":"NA","title":"Propionibacterium Acnes in Shoulder Arthroplasty","status":"COMPLETED","sponsor":"University of Utah","startDate":"2017-01","conditions":"Propionibacterium Acnes","enrollment":62},{"nctId":"NCT03950063","phase":"","title":"Cutibacterium Acnes in Bone and Joint Infections","status":"UNKNOWN","sponsor":"CHU de Reims","startDate":"2019-06-15","conditions":"Prosthesis and Bone Infections, Cutibacterium Acnes","enrollment":50},{"nctId":"NCT03850548","phase":"","title":"Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2016-01-01","conditions":"Bone and Joint Infection","enrollment":6},{"nctId":"NCT01844739","phase":"PHASE1","title":"A Phase 1 Study Evaluating Safety and Tolerability of NVN1000 Gel","status":"COMPLETED","sponsor":"Novan, Inc.","startDate":"2013-04","conditions":"Acne Vulgaris","enrollment":30},{"nctId":"NCT03656588","phase":"NA","title":"Does the Addition of Hydrogen Peroxide to Chlorhexidine Skin Prep to Treat P. Acnes in the Shoulder","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2018-04-16","conditions":"Propionibacterium Infection","enrollment":100},{"nctId":"NCT02602548","phase":"","title":"The Incidence and Incubation Period of False Positive Cultures in Shoulder Surgery","status":"COMPLETED","sponsor":"Forte Sports Medicine and Orthopedics","startDate":"2015-05","conditions":"Infection","enrollment":100},{"nctId":"NCT03115177","phase":"NA","title":"Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?","status":"COMPLETED","sponsor":"Rush University Medical Center","startDate":"2015-11","conditions":"Osteoarthritis","enrollment":56},{"nctId":"NCT02709096","phase":"PHASE2","title":"BPX-01 Minocycline 1% Topical Gel for Reduction of Propionibacterium Acnes","status":"COMPLETED","sponsor":"BioPharmX, Inc.","startDate":"2016-04","conditions":"Acne Vulgaris","enrollment":33},{"nctId":"NCT03009903","phase":"","title":"Evaluation and Detection of Facial Propionibacterium Acnes Bacteria and Phage","status":"UNKNOWN","sponsor":"MBcure Ltd","startDate":"2017-01","conditions":"Acne","enrollment":400},{"nctId":"NCT02688738","phase":"NA","title":"Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2015-03","conditions":"Propionibacterium","enrollment":""},{"nctId":"NCT01688219","phase":"","title":"Immune Response in the SAPHO Syndrome","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2005-11","conditions":"SAPHO Syndrome","enrollment":39},{"nctId":"NCT00211523","phase":"PHASE2","title":"Safety and Efficacy of MBI 226 2.5% and 5.0% Topical Acne Solutions in the Treatment of Acne","status":"COMPLETED","sponsor":"BioWest Therapeutics Inc","startDate":"2000-10","conditions":"Acne Vulgaris, Acne, Propionibacterium Acnes","enrollment":75},{"nctId":"NCT00211497","phase":"PHASE2","title":"Safety and Efficacy of MBI 226 1.25% and 2.5% Topical Acne Solutions in the Treatment of Acne","status":"COMPLETED","sponsor":"BioWest Therapeutics Inc","startDate":"2003-01","conditions":"Acne Vulgaris, Acne, Propionibacterium Acnes","enrollment":255}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3659,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Propionibacterium Acnes","genericName":"Propionibacterium Acnes","companyName":"Treviso Regional Hospital","companyId":"treviso-regional-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propionibacterium acnes is a live bacterial vaccine that stimulates immune responses against the causative organism of acne vulgaris. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}