{"id":"prophylactic-esmolol","safety":{"commonSideEffects":[{"rate":"12-25","effect":"Hypotension"},{"rate":"10-20","effect":"Bradycardia"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Nausea"},{"rate":"3-8","effect":"Fatigue"},{"rate":"2-5","effect":"Dyspnea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Esmolol blocks beta-1 adrenergic receptors on cardiac tissue, decreasing heart contractility and conduction velocity while reducing sympathetic nervous system activity. Its ultra-short half-life (approximately 9 minutes) and rapid onset make it ideal for acute perioperative hemodynamic control. When used prophylactically, it prevents the stress-induced tachycardia and hypertension that occur during anesthesia induction and surgical stimulation.","oneSentence":"Esmolol is a selective beta-1 adrenergic receptor antagonist that rapidly reduces heart rate and blood pressure to prevent perioperative tachycardia and hypertension.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:55.833Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prophylaxis of perioperative tachycardia and hypertension during anesthesia and surgery"},{"name":"Acute intraoperative and postoperative tachycardia management"}]},"trialDetails":[{"nctId":"NCT04264286","phase":"PHASE4","title":"The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation","status":"UNKNOWN","sponsor":"Hospital de Base","startDate":"2019-07-01","conditions":"Beta Blocker, Hemodynamic Instability","enrollment":80},{"nctId":"NCT04086940","phase":"PHASE4","title":"Role of Intraoperative Beta Blocker for Morbid Obese Patients Undergoing Laparoscopic Bariatric Surgery","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2019-11","conditions":"Intraoperative Awareness, Postoperative Pain","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Prophylactic esmolol","genericName":"Prophylactic esmolol","companyName":"Hospital de Base","companyId":"hospital-de-base","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Esmolol is a selective beta-1 adrenergic receptor antagonist that rapidly reduces heart rate and blood pressure to prevent perioperative tachycardia and hypertension. Used for Prophylaxis of perioperative tachycardia and hypertension during anesthesia and surgery, Acute intraoperative and postoperative tachycardia management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}