{"id":"propess-synpitan-fort","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Vaginal irritation or discomfort"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dinoprostone is a naturally occurring prostaglandin E2 analog that binds to prostaglandin receptors on the cervix and uterus, promoting cervical softening, effacement, and dilation while simultaneously stimulating uterine contractions. The sustained-release formulation allows controlled delivery over 12-24 hours, reducing the need for repeated dosing compared to intravenous or intracervical formulations.","oneSentence":"Propess is a sustained-release dinoprostone (prostaglandin E2) vaginal insert that promotes cervical ripening and uterine contractions to induce labor.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:31.204Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening and labor induction in pregnant women at or near term with a medical indication for labor induction"}]},"trialDetails":[{"nctId":"NCT01099280","phase":"PHASE3","title":"Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin","status":"COMPLETED","sponsor":"Erzincan Military Hospital","startDate":"2009-11","conditions":"Labor, Induction, PROM (Pregnancy)","enrollment":225}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Propess,SYNPITAN FORT","genericName":"Propess,SYNPITAN FORT","companyName":"Erzincan Military Hospital","companyId":"erzincan-military-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propess, also known as SYNPITAN FORT, is a small molecule used to induce labor and treat premature rupture of membranes. It works by acting as an external insecticide, although its exact mechanism in this context is not specified.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}