{"id":"propentofylline","rwe":[],"tags":[{"label":"propentofylline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholinesterase","category":"target"},{"label":"ACHE","category":"gene"},{"label":"N06BC02","category":"atc"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Neuroprotective Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"propentophylline","offLabel":[],"synonyms":["propentofylline","propentophylline"],"timeline":[],"aiSummary":"Propentofylline is a small molecule with the synonyms HWA 285, HWA-285, NSC-752424, PROPENTOFILINA, PROPENTOFYLLINE, and PROPENTOFYLLINE.","approvals":[],"brandName":"Propentophylline","ecosystem":[],"mechanism":{"target":"Acetylcholinesterase","targets":[{"gene":"ACHE","source":"DrugCentral","target":"Acetylcholinesterase","protein":"Acetylcholinesterase"}],"modality":"Small Molecule","drugClass":"propentofylline","explanation":"Think of acetylcholine like a messenger in your brain that helps with communication between nerve cells. When acetylcholinesterase breaks it down, the message is lost. By blocking this enzyme, propentofylline allows acetylcholine to stay in the system longer, helping to improve communication between nerve cells.","oneSentence":"Propentofylline works by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.","technicalDetail":"Propentofylline acts as a non-competitive inhibitor of acetylcholinesterase, increasing the concentration and duration of action of acetylcholine in the synaptic cleft."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2296","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PROPENTOFYLLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:27:00.170047","biosimilars":[],"competitors":[{"drugName":"caffeine","drugSlug":"caffeine","fdaApproval":"1948-11-26","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"propentofylline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"caffeine","brandName":"caffeine","genericName":"caffeine","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"008166","UNII":"5RTA398U4H","CHEBI":"CHEBI:32061","INN_ID":"5005","RXNORM":"34644","UMLSCUI":"C0072171","ChEMBL_ID":"CHEMBL1079905","KEGG_DRUG":"D01630","DRUGBANK_ID":"DB06479","PDB_CHEM_ID":" POY","PUBCHEM_CID":"4938","MESH_SUPPLEMENTAL_RECORD_UI":"C032114"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":263,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06BC02","allCodes":["N06BC02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}