{"id":"propamidine-0-1","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Eye irritation"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Eye pain"}]},"_chembl":{"chemblId":"CHEMBL23013","moleculeType":"Small molecule","molecularWeight":"312.37"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Propamidine acts by interfering with the protozoa's ability to synthesize proteins, ultimately leading to cell death. This mechanism is effective against a range of protozoal infections, including those caused by Acanthamoeba and Naegleria. By inhibiting the growth of these pathogens, propamidine helps to prevent the spread of infection and promote healing.","oneSentence":"Propamidine is an antiprotozoal agent that works by inhibiting the growth of protozoa.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:24.259Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acanthamoeba keratitis"},{"name":"Naegleria fowleri infection"}]},"trialDetails":[{"nctId":"NCT03274895","phase":"PHASE3","title":"Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis","status":"COMPLETED","sponsor":"SIFI SpA","startDate":"2017-08-13","conditions":"Acanthamoeba Keratitis","enrollment":135}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brolene eye drops"],"phase":"phase_3","status":"active","brandName":"Propamidine 0.1%","genericName":"Propamidine 0.1%","companyName":"SIFI SpA","companyId":"sifi-spa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propamidine 0.1% is a small molecule used in ophthalmic solutions. It has been studied in a clinical trial for the treatment of Acanthamoeba Keratitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}