{"id":"propafenone-i-v","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"3-8","effect":"Nausea"},{"rate":"2-5","effect":"Blurred vision"},{"rate":"1-3","effect":"Proarrhythmic effects"},{"rate":"2-5","effect":"Bradycardia"},{"rate":"1-3","effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propafenone inhibits the fast inward sodium current in cardiac tissue, which decreases the rate of depolarization and slows conduction through the atria and ventricles. This sodium channel blockade also has weak beta-blocking and calcium channel blocking properties. The net effect is suppression of ectopic arrhythmias and stabilization of abnormal cardiac rhythms.","oneSentence":"Propafenone is a Class IC antiarrhythmic agent that blocks cardiac sodium channels to slow conduction velocity and suppress abnormal electrical activity in the heart.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:40.679Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation (maintenance of sinus rhythm)"},{"name":"Paroxysmal supraventricular tachycardia"},{"name":"Ventricular arrhythmias"}]},"trialDetails":[{"nctId":"NCT03029169","phase":"PHASE4","title":"Propafenone Versus Amiodarone in Septic Shock","status":"COMPLETED","sponsor":"Charles University, Czech Republic","startDate":"2017-10-23","conditions":"Supraventricular Arrhythmia, Septic Shock","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Antiarrhythmic therapy"],"phase":"marketed","status":"active","brandName":"Propafenone i.v.","genericName":"Propafenone i.v.","companyName":"Charles University, Czech Republic","companyId":"charles-university-czech-republic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propafenone i.v. is used to treat supraventricular arrhythmia and septic shock, as per clinical trials. Its mechanism of action is as a class Ic antiarrhythmic agent, according to ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}