{"id":"promescent-lidocaine-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Penile numbness or reduced sensation"},{"rate":null,"effect":"Local irritation or erythema"},{"rate":null,"effect":"Temporary loss of erectile function"},{"rate":null,"effect":"Partner genital numbness (from transfer)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that blocks sodium channels in nerve fibers, reducing the conduction of pain and sensory signals. When applied topically to the penis, it decreases penile sensitivity, thereby prolonging the time to ejaculation and improving control during sexual activity. This mechanism addresses premature ejaculation by desensitizing the tissue without systemic absorption.","oneSentence":"Lidocaine spray topically anesthetizes nerve endings in penile tissue to reduce sensory stimulation and delay ejaculation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:25.072Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Premature ejaculation"}]},"trialDetails":[{"nctId":"NCT02241460","phase":"PHASE3","title":"Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation","status":"UNKNOWN","sponsor":"Eugene Y Rhee, MD","startDate":"2014-03","conditions":"Premature Ejaculation","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Promescent Lidocaine Spray","genericName":"Promescent Lidocaine Spray","companyName":"Eugene Y Rhee, MD","companyId":"eugene-y-rhee-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine spray topically anesthetizes nerve endings in penile tissue to reduce sensory stimulation and delay ejaculation. Used for Premature ejaculation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}