{"id":"promegestone","rwe":[{"pmid":"41732194","year":"2026","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","finding":"","journal":"EClinicalMedicine","studyType":"Clinical Study"},{"pmid":"40381587","year":"2025","title":"Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk.","finding":"","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia","studyType":"Clinical Study"},{"pmid":"40353175","year":"2025","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","finding":"","journal":"Surgical neurology international","studyType":"Clinical Study"},{"pmid":"39996716","year":"2025","title":"Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.","finding":"","journal":"Cells","studyType":"Clinical Study"},{"pmid":"38537944","year":"2024","title":"Use of progestogens and the risk of intracranial meningioma: national case-control study.","finding":"","journal":"BMJ (Clinical research ed.)","studyType":"Clinical Study"}],"tags":[{"label":"promegestone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Progesterone receptor","category":"target"},{"label":"PGR","category":"gene"},{"label":"G03DB07","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"surgestone","offLabel":[],"synonyms":["promegestone","surgestone"],"timeline":[],"aiSummary":"Surgestone, also known as promegestone, is a synthetic progestogen that targets the progesterone receptor. It is a small molecule drug of the promegestone class, but its current commercial status and approved indications are unknown. As a progestogen, it works by binding to the progesterone receptor, which plays a crucial role in the menstrual cycle and pregnancy. However, without more information on its approved indications and commercial status, it is difficult to provide a comprehensive summary. Further research is needed to determine its potential uses and safety considerations.","approvals":[],"brandName":"Surgestone","ecosystem":[],"mechanism":{"target":"Progesterone receptor, Androgen receptor","targets":[{"gene":"PGR","source":"DrugCentral","target":"Progesterone receptor","protein":"Progesterone receptor"}],"modality":"Small Molecule","drugClass":"promegestone","explanation":"Imagine your body has a lock that only progesterone can open. Surgestone is a key that fits into that lock, allowing it to turn on or off certain processes in the body. This can help regulate the menstrual cycle and support pregnancy.","oneSentence":"Surgestone works by binding to the progesterone receptor, mimicking the effects of the natural hormone progesterone.","technicalDetail":"Surgestone is a selective progesterone receptor modulator (SPRM) that binds to the progesterone receptor with high affinity, activating or inhibiting downstream signaling pathways depending on the context."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2285","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PROMEGESTONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:26:38.211123","biosimilars":[],"competitors":[{"drugName":"dydrogesterone","drugSlug":"dydrogesterone","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dienogest","drugSlug":"dienogest","fdaApproval":"2010-05-06","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"promegestone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dydrogesterone","brandName":"dydrogesterone","genericName":"dydrogesterone","approvalYear":"","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"dienogest","brandName":"dienogest","genericName":"dienogest","approvalYear":"2010","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167398","NDDF":"005721","UNII":"9XE0V2SQYX","CHEBI":"CHEBI:73390","INN_ID":"4287","RXNORM":"8744","UMLSCUI":"C0033401","ChEMBL_ID":"CHEMBL196003","KEGG_DRUG":"D08431","DRUGBANK_ID":"DB13602","PUBCHEM_CID":"36709","SNOMEDCT_US":"713439003","IUPHAR_LIGAND_ID":"2877","MESH_DESCRIPTOR_UI":"D011397"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":205,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DB07","allCodes":["G03DB07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41732194","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","journal":"EClinicalMedicine"},{"date":"2025 Jul","pmid":"40381587","title":"Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk.","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia"},{"date":"2025","pmid":"40353175","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","journal":"Surgical neurology international"},{"date":"2025 Feb 7","pmid":"39996716","title":"Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.","journal":"Cells"},{"date":"2024 Mar 27","pmid":"38537944","title":"Use of progestogens and the risk of intracranial meningioma: national case-control study.","journal":"BMJ (Clinical research ed.)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}