{"id":"prolyl-endopeptidase","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prolyl endopeptidase (PEP) is a serine protease that specifically hydrolyzes peptide bonds on the C-terminal side of proline residues. This enzymatic activity may influence the metabolism of bioactive peptides involved in gastrointestinal function, potentially affecting motility, secretion, and nutrient absorption. The enzyme's role in peptide processing suggests therapeutic applications in gastrointestinal disorders.","oneSentence":"Prolyl endopeptidase is an enzyme that cleaves peptide bonds after proline residues, potentially modulating neuropeptide and protein processing in the gastrointestinal and nervous systems.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:36:39.709Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastrointestinal disorders (specific indication unclear from available information)"}]},"trialDetails":[{"nctId":"NCT07465562","phase":"NA","title":"Galactol® Enzyme Supplement for Post-Prandial Abdominal Bloating in Irritable Bowel Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2026-03-16","conditions":"Irritable Bowel Syndrome, Abdominal Bloating","enrollment":300},{"nctId":"NCT04788797","phase":"PHASE4","title":"AN-PEP on Gluten Exposure in Celiacs","status":"COMPLETED","sponsor":"Dr. C. Bonorino Udaondo Gastroenterology Hospital","startDate":"2021-03-17","conditions":"Celiac Disease","enrollment":40},{"nctId":"NCT02060864","phase":"NA","title":"Effect of AN-PEP Enzyme on Gluten Digestion in Gluten Sensitive Individuals","status":"COMPLETED","sponsor":"DSM Food Specialties","startDate":"2014-04","conditions":"Non-coeliac Gluten Sensitivity","enrollment":18},{"nctId":"NCT01917630","phase":"PHASE2","title":"Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients","status":"UNKNOWN","sponsor":"Alvine Pharmaceuticals Inc.","startDate":"2013-08","conditions":"Celiac Disease","enrollment":500},{"nctId":"NCT00959114","phase":"PHASE2","title":"Safety and Efficacy of ALV003 for the Treatment of Celiac Disease","status":"COMPLETED","sponsor":"Alvine Pharmaceuticals Inc.","startDate":"2009-08","conditions":"Celiac Disease","enrollment":74},{"nctId":"NCT01255696","phase":"PHASE2","title":"Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease","status":"COMPLETED","sponsor":"Alvine Pharmaceuticals Inc.","startDate":"2010-11","conditions":"Celiac Disease","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GliadinX"],"phase":"marketed","status":"active","brandName":"Prolyl Endopeptidase","genericName":"Prolyl Endopeptidase","companyName":"Dr. C. Bonorino Udaondo Gastroenterology Hospital","companyId":"dr-c-bonorino-udaondo-gastroenterology-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prolyl Endopeptidase is an enzyme being studied for its potential to aid in the digestion of gluten in individuals with Non-coeliac Gluten Sensitivity, Celiac Disease, Irritable Bowel Syndrome, and Abdominal Bloating. It is being investigated as part of the AN-PEP intervention in clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}