{"id":"progesterone-ibsa-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone that acts as a ligand for intracellular progesterone receptors (PR-A and PR-B). Upon binding, it modulates gene transcription to promote endometrial secretion, suppress uterine contractions, and maintain the corpus luteum, thereby supporting early pregnancy maintenance and preventing miscarriage.","oneSentence":"Progesterone binds to progesterone receptors in the uterus and other reproductive tissues to maintain pregnancy and regulate the menstrual cycle.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:23.200Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART)"},{"name":"Threatened or recurrent miscarriage prevention"}]},"trialDetails":[{"nctId":"NCT04549116","phase":"PHASE3","title":"Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.","status":"ACTIVE_NOT_RECRUITING","sponsor":"IBSA Institut Biochimique SA","startDate":"2022-10-12","conditions":"Infertility","enrollment":680},{"nctId":"NCT05276531","phase":"NA","title":"Comparison of the Effect of Subcutaneous Progesterone and Vaginal Progesterone for Luteal Phase Support","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2022-04-01","conditions":"Progesterone","enrollment":146}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":257,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prolutex"],"phase":"phase_3","status":"active","brandName":"Progesterone-IBSA Injectable Solution","genericName":"Progesterone-IBSA Injectable Solution","companyName":"IBSA Institut Biochimique SA","companyId":"ibsa-institut-biochimique-sa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone binds to progesterone receptors in the uterus and other reproductive tissues to maintain pregnancy and regulate the menstrual cycle. Used for Luteal phase support in assisted reproductive technology (ART), Threatened or recurrent miscarriage prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}