{"id":"progesteron-tid","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness or sedation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL3792620","moleculeType":"Small molecule","molecularWeight":"722.78"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Progesterone binds to intracellular progesterone receptors (PR-A and PR-B), which translocate to the nucleus and regulate transcription of target genes. This mechanism is fundamental to maintaining pregnancy, regulating the menstrual cycle, and modulating immune and metabolic functions. The TID (three times daily) dosing regimen suggests use of a micronized or bioavailable formulation to achieve therapeutic levels.","oneSentence":"Progesterone acts as a ligand for progesterone receptors, modulating gene transcription and hormonal signaling pathways involved in reproductive and metabolic processes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:20.966Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Recurrent miscarriage prevention"},{"name":"Preterm birth prevention"}]},"trialDetails":[{"nctId":"NCT04806919","phase":"PHASE3","title":"Luteal Support in Artificial Vitrified/Warmed Cycles With Low Progesterone","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2021-04-02","conditions":"IVF, Embryo Loss, Luteal Phase Defect","enrollment":87},{"nctId":"NCT04872660","phase":"PHASE4","title":"Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET","status":"RECRUITING","sponsor":"Shandong University of Traditional Chinese Medicine","startDate":"2021-06-15","conditions":"Infertility, Female","enrollment":800},{"nctId":"NCT05555121","phase":"PHASE2","title":"Rescue Progesterone Supplementation During Frozen Embryo Transfer","status":"SUSPENDED","sponsor":"Clinique Ovo","startDate":"2022-12-01","conditions":"Fertility Issues, Embryo Implantation, Frozen Embryo Transfer","enrollment":150},{"nctId":"NCT06668896","phase":"PHASE1","title":"Comparing the Pharmacokinetics of a Progesterone Ring Versus a Progesterone Vaginal Insert","status":"NOT_YET_RECRUITING","sponsor":"Daré Bioscience, Inc.","startDate":"2025-11","conditions":"Pre Term Birth","enrollment":60},{"nctId":"NCT03642665","phase":"PHASE4","title":"Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2018-09-25","conditions":"Embryo Transfer","enrollment":554},{"nctId":"NCT05473273","phase":"","title":"Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2023-04-24","conditions":"Infertility, Female","enrollment":40},{"nctId":"NCT06644794","phase":"PHASE3","title":"Progesterone-modified Natural Cycle for FET","status":"NOT_YET_RECRUITING","sponsor":"Shandong University of Traditional Chinese Medicine","startDate":"2024-12-05","conditions":"Infertility, Female","enrollment":336},{"nctId":"NCT06616077","phase":"EARLY_PHASE1","title":"Endometrial Transcript Profile with Progesterone After Post-ovulatory Mifepristone","status":"COMPLETED","sponsor":"Reproductive Health Research Insritute, Chile","startDate":"2022-06-07","conditions":"Endometrial Endocrine Regulation, Progesterone Supplementation in Women After Mifepristone","enrollment":9},{"nctId":"NCT05899010","phase":"PHASE3","title":"MIcronized PROgesterone in Frozen Embryo Transfer Cycles","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2023-07-05","conditions":"Infertility","enrollment":1020},{"nctId":"NCT04758871","phase":"PHASE4","title":"Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles","status":"COMPLETED","sponsor":"CRG UZ Brussel","startDate":"2021-10-01","conditions":"Frozen Embryo Transfer, Hormone Replacement Therapy, Dydrogesterone","enrollment":150},{"nctId":"NCT01425541","phase":"NA","title":"Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition","status":"UNKNOWN","sponsor":"University of Virginia","startDate":"2000-04","conditions":"Hyperandrogenemia, Polycystic Ovary Syndrome (PCOS)","enrollment":60},{"nctId":"NCT05484193","phase":"NA","title":"GnRH Agonist for Luteal Phase Support.","status":"UNKNOWN","sponsor":"Shaare Zedek Medical Center","startDate":"2020-06-08","conditions":"Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles","enrollment":150},{"nctId":"NCT04797338","phase":"PHASE4","title":"Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders","status":"UNKNOWN","sponsor":"Assaf-Harofeh Medical Center","startDate":"2017-12-29","conditions":"Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome","enrollment":100},{"nctId":"NCT03946722","phase":"PHASE4","title":"Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer.","status":"UNKNOWN","sponsor":"University College, London","startDate":"2020-08-17","conditions":"Adenomyosis","enrollment":162},{"nctId":"NCT03677336","phase":"PHASE4","title":"Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI","status":"COMPLETED","sponsor":"CRG UZ Brussel","startDate":"2019-05-01","conditions":"Infertility, Female, Infertility, Genital Diseases, Male","enrollment":30},{"nctId":"NCT03832699","phase":"NA","title":"Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer","status":"UNKNOWN","sponsor":"Wolfson Medical Center","startDate":"2019-03-01","conditions":"ART","enrollment":100},{"nctId":"NCT04124913","phase":"PHASE4","title":"Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles","status":"UNKNOWN","sponsor":"Memorial Sisli Hospital, Istanbul","startDate":"2019-01-02","conditions":"Infertility, Female, Infertility, Male, Embryo Transfer","enrollment":140},{"nctId":"NCT02491437","phase":"PHASE3","title":"A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)","status":"COMPLETED","sponsor":"Abbott","startDate":"2015-07","conditions":"Female Infertility","enrollment":1034},{"nctId":"NCT01940653","phase":"PHASE4","title":"Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2012-11","conditions":"Progesterone Supplementation","enrollment":300},{"nctId":"NCT02032797","phase":"PHASE4","title":"Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2012-11","conditions":"Cryopreservation, Embryo Implantation, Progesteron","enrollment":300},{"nctId":"NCT02486757","phase":"EARLY_PHASE1","title":"Investigation of Female Reproductive Hormone Dynamics During Adolescence","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2015-04","conditions":"Menstruation Disturbances","enrollment":9},{"nctId":"NCT02148393","phase":"NA","title":"Implantation Enhancement by Elective Cryopreservation of All Viable Embryos","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2014-05","conditions":"Infertility, OHSS","enrollment":212},{"nctId":"NCT01850030","phase":"PHASE3","title":"A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization","status":"COMPLETED","sponsor":"Abbott","startDate":"2013-08","conditions":"Female Infertility","enrollment":1070},{"nctId":"NCT02989519","phase":"PHASE3","title":"Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor","status":"COMPLETED","sponsor":"Sanpasitthiprasong Hospital","startDate":"2015-08","conditions":"Preterm Delivery","enrollment":231},{"nctId":"NCT02677259","phase":"PHASE2","title":"Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles","status":"UNKNOWN","sponsor":"One Fertility","startDate":"2016-05","conditions":"IVF","enrollment":506},{"nctId":"NCT01204840","phase":"PHASE2","title":"Growth Hormone for Poor Responders in in Vitro Fertilization (IVF)","status":"COMPLETED","sponsor":"Ottawa Fertility Centre","startDate":"2010-09","conditions":"Infertility, Poor Ovarian Reserve","enrollment":38},{"nctId":"NCT01985594","phase":"PHASE2","title":"Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial","status":"UNKNOWN","sponsor":"nor zila hassan malek","startDate":"2013-11","conditions":"Preterm Labor","enrollment":32},{"nctId":"NCT00805935","phase":"PHASE4","title":"Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2009-01","conditions":"Polycystic Ovarian Syndrome, Infertility","enrollment":110},{"nctId":"NCT01465373","phase":"PHASE4","title":"Vaginal Progesterone Versus Progesterone in Oil in Donor Egg Recipient In Vitro Fertilization Cycles Utilizing Vitrified Donor Eggs","status":"COMPLETED","sponsor":"Fertility Centers of Illinois","startDate":"2010-02","conditions":"Infertility","enrollment":10},{"nctId":"NCT00802360","phase":"PHASE4","title":"MENOPUR® Versus FOLLISTIM®","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2008-12","conditions":"Infertility","enrollment":173},{"nctId":"NCT00296478","phase":"PHASE3","title":"Multi-Center, Randomized, Open-Label, Parallel Group Study of a Vaginal Micronized Progesterone Tablet (Endometrin®) Compared to Crinone 8% Vaginal Gel in Female Patients Undergoing In-Vitro Fertilization (IVF)","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2005-07","conditions":"Fertility","enrollment":1211},{"nctId":"NCT00708539","phase":"PHASE4","title":"A Prospective Randomized Multicentre Study to Compare Crinone 8% Once Daily Versus Other Vaginal Progesterone.","status":"UNKNOWN","sponsor":"Nordica Fertility Clinic","startDate":"2006-04","conditions":"IVF - Luteal Phase Support After Embryo Transfer","enrollment":2686}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Progesteron TID","genericName":"Progesteron TID","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone acts as a ligand for progesterone receptors, modulating gene transcription and hormonal signaling pathways involved in reproductive and metabolic processes. Used for Recurrent miscarriage prevention, Preterm birth prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}