{"id":"procalcitonin-guided-antibiotic-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Increased risk of antibiotic resistance"},{"rate":null,"effect":"Potential for delayed diagnosis and treatment of bacterial infections"}]},"_chembl":{"chemblId":"CHEMBL2207138","moleculeType":"Protein","molecularWeight":"3475.94"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Procalcitonin is a peptide hormone that is produced in response to bacterial infections. By measuring procalcitonin levels, healthcare providers can determine the likelihood of a bacterial infection and make informed decisions about antibiotic therapy. This approach aims to reduce unnecessary antibiotic use and minimize the development of antibiotic resistance.","oneSentence":"Procalcitonin-guided antibiotic therapy involves using procalcitonin levels to guide the initiation and discontinuation of antibiotic therapy in patients with suspected bacterial infections.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:14.247Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Community-acquired pneumonia"},{"name":"Hospital-acquired pneumonia"},{"name":"Ventilator-associated pneumonia"}]},"trialDetails":[{"nctId":"NCT06478953","phase":"PHASE2","title":"Impact of Rapid Pathogen Detection in ICU Patients With Suspected Pneumonia on Antimicrobial Therapy","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2024-06-26","conditions":"Pneumonia, Critically Ill","enrollment":40},{"nctId":"NCT07382375","phase":"NA","title":"AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection","status":"NOT_YET_RECRUITING","sponsor":"Nanjing Medical University","startDate":"2027-12-31","conditions":"Aortic Aneurysm and Dissection","enrollment":300},{"nctId":"NCT05909683","phase":"PHASE3","title":"Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hellenic Institute for the Study of Sepsis","startDate":"2023-09-19","conditions":"Sepsis","enrollment":190},{"nctId":"NCT07211620","phase":"NA","title":"KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic Use - Comparing Procalcitonin Kinetics-guided and Absolute Procalcitonin Value-guided Antibiotic Initiation in Reducing Unnecessary Antibiotic Use in Critically Ill Patients","status":"RECRUITING","sponsor":"Semmelweis University","startDate":"2025-11-06","conditions":"Infection, Sepsis","enrollment":250},{"nctId":"NCT03730636","phase":"NA","title":"Procalcitonin and Duration of AntiBiotherapy In Late Onset Sepsis of Neonate","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-02-15","conditions":"Sepsis","enrollment":511},{"nctId":"NCT06301841","phase":"NA","title":"An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care","status":"RECRUITING","sponsor":"University Hospital, Caen","startDate":"2024-05-07","conditions":"To Reduce Duration of Antibiotics Exposure in Patients With COPD Hospitalized in Intensive Care Unit With Pneumonia","enrollment":64},{"nctId":"NCT06960044","phase":"NA","title":"Procalcitonin Aided Antimicrobial Therapy vs Standard of Care","status":"NOT_YET_RECRUITING","sponsor":"Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria","startDate":"2025-06-01","conditions":"Lower Respiratory Tract Infection (LRTI)","enrollment":108},{"nctId":"NCT04158804","phase":"NA","title":"PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2020-05-28","conditions":"Pneumonia, Bacterial","enrollment":700},{"nctId":"NCT03388944","phase":"NA","title":"PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis","status":"COMPLETED","sponsor":"All India Institute of Medical Sciences","startDate":"2019-10-21","conditions":"Sepsis, Septic Shock, Antibiotic Use","enrollment":561},{"nctId":"NCT05350813","phase":"NA","title":"Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy","status":"RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2023-05-02","conditions":"Bacterial Infections","enrollment":296},{"nctId":"NCT06395454","phase":"NA","title":"Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU","status":"NOT_YET_RECRUITING","sponsor":"Universiti Sains Malaysia","startDate":"2024-07-01","conditions":"Antibiotic Side Effect","enrollment":48},{"nctId":"NCT05854901","phase":"NA","title":"PCT-guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations","status":"UNKNOWN","sponsor":"Erasmus Medical Center","startDate":"2021-08-10","conditions":"COPD Exacerbation, COPD, Acute Copd Exacerbation","enrollment":693},{"nctId":"NCT05796115","phase":"NA","title":"PROcalcitonin and Presepsin-guided Decision for Antibiotic Prophylaxis of EOS","status":"UNKNOWN","sponsor":"University of Florence","startDate":"2023-04-01","conditions":"Early-Onset Neonatal Sepsis","enrollment":266},{"nctId":"NCT04216277","phase":"NA","title":"The Procalcitonin Guided Antibiotics in Respiratory Infections in General Practice","status":"WITHDRAWN","sponsor":"Chronic Obstructive Pulmonary Disease Trial Network, Denmark","startDate":"2020-02-27","conditions":"Acute Respiratory Tract Infection","enrollment":""},{"nctId":"NCT02173613","phase":"NA","title":"Reduction the Duration of Antibiotic Therapy in the Elderly (PROPAGE)","status":"TERMINATED","sponsor":"University Hospital, Grenoble","startDate":"2012-08","conditions":"Lung Infection","enrollment":117},{"nctId":"NCT01264549","phase":"NA","title":"Stroke Adverse Outcome is Associated With Nosocomial Infections: PCTus- Guided Antibacterial Therapy in Severe Ischemic Stroke Patients (STRAWINSKI)","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2010-12","conditions":"Ischemic Stroke","enrollment":230},{"nctId":"NCT04240288","phase":"NA","title":"Procalcitonin Guided Antibiotic Therapy","status":"WITHDRAWN","sponsor":"Columbia University","startDate":"2021-09","conditions":"Intra-Abdominal Infections","enrollment":""},{"nctId":"NCT04563104","phase":"","title":"Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2020-10-01","conditions":"Ventilator Associated Pneumonia","enrollment":62},{"nctId":"NCT02261610","phase":"NA","title":"Pulmonary Embolism and PCT. PE-PCT Study","status":"TERMINATED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2014-11-26","conditions":"Pulmonary Embolism With Fever","enrollment":18},{"nctId":"NCT04682899","phase":"PHASE3","title":"A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease","status":"UNKNOWN","sponsor":"Capital Medical University","startDate":"2021-02-01","conditions":"Procalcitonin, Chronic Obstructive Pulmonary Disease","enrollment":500},{"nctId":"NCT03982667","phase":"NA","title":"Research Title: Efficacy and Safety of Point- Of-care Procalcitonin Test to Reduce Antibiotic Exposure in VAP","status":"COMPLETED","sponsor":"Mohd Zulfakar Mazlan, MBBS","startDate":"2019-06-15","conditions":"Ventilator Associated Pneumonia","enrollment":100},{"nctId":"NCT03440918","phase":"NA","title":"Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2018-02-12","conditions":"Sepsis, Procalcitonin, Antimicrobial Stewardship","enrollment":271},{"nctId":"NCT03333304","phase":"NA","title":"A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis","status":"COMPLETED","sponsor":"Hellenic Institute for the Study of Sepsis","startDate":"2017-10-24","conditions":"Sepsis","enrollment":266},{"nctId":"NCT03440060","phase":"NA","title":"Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPD","status":"UNKNOWN","sponsor":"University Hospital, Mahdia","startDate":"2017-10-05","conditions":"Acute Exacerbation Copd","enrollment":100},{"nctId":"NCT02202941","phase":"NA","title":"Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-08","conditions":"Sepsis","enrollment":62},{"nctId":"NCT03109106","phase":"NA","title":"Procalcitonin for Stewardship in Respiratory Infections A Stewardship Project","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2017-04-15","conditions":"LRTI","enrollment":189},{"nctId":"NCT02392689","phase":"NA","title":"Improve Management of Heart Failure With Procalcitonin","status":"TERMINATED","sponsor":"Brahms AG","startDate":"2015-03","conditions":"Heart Failure, Infection","enrollment":759},{"nctId":"NCT01723644","phase":"NA","title":"Clinical Reassessment Versus Procalcitonin in Order to Shorten Antibiotic Duration in Community-acquired Pneumonia","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2012-10","conditions":"Community-acquired Pneumonia","enrollment":286},{"nctId":"NCT03146182","phase":"NA","title":"Biomarker Guided Antibiotic Treatment in Community-Acquired Pneumonia","status":"UNKNOWN","sponsor":"Gertrud Baunbaek Egelund","startDate":"2017-03-15","conditions":"Community Acquired Pneumonia","enrollment":300},{"nctId":"NCT03058718","phase":"NA","title":"Procalcitonin-Guided Antibiotic Therapy in Bronchiectasis","status":"COMPLETED","sponsor":"Qilu Hospital of Shandong University","startDate":"2014-01-01","conditions":"Procalcitonin, Bronchiectasis, Antibiotic Therapy","enrollment":210},{"nctId":"NCT00832039","phase":"PHASE3","title":"Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis","status":"COMPLETED","sponsor":"Kompetenznetz Sepsis","startDate":"2009-11","conditions":"Severe Sepsis, Septic Shock","enrollment":1089},{"nctId":"NCT00854932","phase":"NA","title":"Neonatal Procalcitonin Intervention Study","status":"UNKNOWN","sponsor":"Luzerner Kantonsspital","startDate":"2009-06","conditions":"Sepsis","enrollment":1600},{"nctId":"NCT00934011","phase":"NA","title":"Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2009-09","conditions":"Severe Sepsis, Septic Shock","enrollment":94},{"nctId":"NCT01018199","phase":"NA","title":"Procalcitonin Versus C-reactive Protein to Guide Therapy in Community Acquired Pneumonia","status":"WITHDRAWN","sponsor":"Federal University of Minas Gerais","startDate":"2016-01","conditions":"Community-acquired Pneumonia","enrollment":""},{"nctId":"NCT01139489","phase":"NA","title":"Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)","status":"COMPLETED","sponsor":"Amsterdam UMC, location VUmc","startDate":"2009-11","conditions":"Sepsis, Severe Sepsis, Septic Shock","enrollment":1575},{"nctId":"NCT00987818","phase":"NA","title":"Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU","status":"WITHDRAWN","sponsor":"Rijnstate Hospital","startDate":"","conditions":"Sepsis, Intensive Care","enrollment":""},{"nctId":"NCT02521636","phase":"NA","title":"Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care","status":"UNKNOWN","sponsor":"University Hospital, Caen","startDate":"2010-10","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":300},{"nctId":"NCT01572831","phase":"PHASE3","title":"PCT and Clinical Algorithm for Determination of Duration of Antibiotics","status":"COMPLETED","sponsor":"Fraser Health","startDate":"2012-05","conditions":"Infection","enrollment":1},{"nctId":"NCT01125098","phase":"","title":"Comparison of a Serum PRO-CT Guided Treatment and the Recommended Antibiotic Treatment for COPD","status":"COMPLETED","sponsor":"University of Modena and Reggio Emilia","startDate":"2006-10","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":183},{"nctId":"NCT01788488","phase":"NA","title":"Procalcitonin Use in Pneumonia Patients in the Critical Care Setting","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2013-02","conditions":"Pneumonia","enrollment":134},{"nctId":"NCT01379547","phase":"PHASE3","title":"Procalcitonin to Shorten Antibiotics Duration in ICU Patients","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2011-06","conditions":"Sepsis","enrollment":1700},{"nctId":"NCT01652404","phase":"PHASE3","title":"PROcalcitonin to SHORTen Antibiotics Duration in PEDiatricICU Patients (ProShort-Ped) Trial","status":"UNKNOWN","sponsor":"Hunan Children's Hospital","startDate":"2011-03","conditions":"Sepsis","enrollment":600},{"nctId":"NCT00407147","phase":"PHASE4","title":"Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection","status":"TERMINATED","sponsor":"Brahms AG","startDate":"2008-07","conditions":"Infection, Bacterial Infection, Sepsis","enrollment":11},{"nctId":"NCT00928291","phase":"NA","title":"Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2010-01","conditions":"Febrile Neutropenia","enrollment":60},{"nctId":"NCT01025180","phase":"PHASE4","title":"Study of Procalcitonin (PCT)-Guided Antibiotic Use in Severe Sepsis Patients Without Obvious Infection","status":"TERMINATED","sponsor":"Brahms France","startDate":"2007-12","conditions":"Severe Sepsis","enrollment":62},{"nctId":"NCT01085994","phase":"","title":"Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit","status":"UNKNOWN","sponsor":"University of Athens","startDate":"2010-01","conditions":"Sepsis","enrollment":""},{"nctId":"NCT00271752","phase":"NA","title":"The Procalcitonin and Survival Study","status":"COMPLETED","sponsor":"Danish Procalcitonin Study Group","startDate":"2006-01","conditions":"Localized 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Used for Community-acquired pneumonia, Hospital-acquired pneumonia, Ventilator-associated pneumonia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}