{"id":"probiotic-plus-lactulose","safety":{"commonSideEffects":[{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Flatulence"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Diarrhea (from lactulose)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Probiotics introduce live beneficial microorganisms (typically Lactobacillus and Bifidobacterium species) to restore healthy gut flora, while lactulose, a non-absorbable disaccharide, increases stool bulk and osmotic pressure to promote bowel movements. Together, they work synergistically to improve intestinal function, enhance nutrient absorption, and support the gut microbiome balance.","oneSentence":"Probiotics restore beneficial gut bacteria while lactulose acts as a prebiotic osmotic laxative to promote bowel regularity and support gastrointestinal health.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:02:42.817Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation and irregular bowel movements"},{"name":"Gastrointestinal dysbiosis and microbiome imbalance"},{"name":"Digestive health support"}]},"trialDetails":[{"nctId":"NCT07360535","phase":"PHASE2","title":"Effect of Probiotic on Gut Microbiota in Young Children With Functional Constipation","status":"RECRUITING","sponsor":"Min-Tze LIONG","startDate":"2020-06-10","conditions":"Functional Constipation in Children","enrollment":150},{"nctId":"NCT07037394","phase":"PHASE4","title":"A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy.","status":"COMPLETED","sponsor":"Qurratul Ain Jamil","startDate":"2024-12-02","conditions":"Overt Hepatic Encephalopathy","enrollment":252},{"nctId":"NCT06317441","phase":"NA","title":"The Safety And Efficacy Of A Probiotic Intervention On Lactulose Hydrogen Breath Test-Positive Patients And Related Gastrointestinal Symptoms","status":"RECRUITING","sponsor":"Nimble Science Ltd.","startDate":"2024-07-20","conditions":"Small Intestinal Bacterial Overgrowth, SIBO","enrollment":105},{"nctId":"NCT06802042","phase":"NA","title":"Effect of Lactobacillus DSM17938+ on Functional Constipation and Intestinal Flora in Pregnant Women","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-01-09","conditions":"Functional Constipation (FC)","enrollment":40},{"nctId":"NCT05687409","phase":"PHASE4","title":"Synbiotics Interventions for Managing Cirrhosis and Its Complications","status":"COMPLETED","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2019-11-24","conditions":"Cirrhosis, Liver, Metagonimiasis","enrollment":120},{"nctId":"NCT04787276","phase":"NA","title":"Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy","status":"COMPLETED","sponsor":"Bogomolets National Medical University","startDate":"2017-01-10","conditions":"Hepatic Encephalopathy, Liver Cirrhosis, End Stage Liver DIsease","enrollment":42},{"nctId":"NCT03659175","phase":"","title":"Characteristic of Intestinal Flora in Male Elderly With Small Intestinal Bacterial Overgrowth","status":"UNKNOWN","sponsor":"Chinese PLA General Hospital","startDate":"2018-10-15","conditions":"Small Intestinal Bacterial Overgrowth, Elderly, Male","enrollment":40},{"nctId":"NCT01252550","phase":"NA","title":"Effects of Activia in IBS","status":"COMPLETED","sponsor":"Sahlgrenska University Hospital","startDate":"2010-05","conditions":"Irritable Bowel Syndrome","enrollment":100},{"nctId":"NCT01008293","phase":"PHASE2, PHASE3","title":"Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life","status":"COMPLETED","sponsor":"CD Pharma India Pvt. Ltd.","startDate":"2009-10","conditions":"Chronic Liver Disease, Hepatic Encephalopathy","enrollment":120},{"nctId":"NCT01587846","phase":"PHASE3","title":"Lactobacillus Reuteri in Treatment of Functional Abdominal Pain and Chronic Constipation in Children","status":"UNKNOWN","sponsor":"Sisters of Mercy University Hospital","startDate":"2012-10","conditions":"Abdominal Pain, Constipation - Functional","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ecotec plus Duphalac"],"phase":"marketed","status":"active","brandName":"Probiotic plus lactulose","genericName":"Probiotic plus lactulose","companyName":"Qurratul Ain Jamil","companyId":"qurratul-ain-jamil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Probiotics restore beneficial gut bacteria while lactulose acts as a prebiotic osmotic laxative to promote bowel regularity and support gastrointestinal health. Used for Constipation and irregular bowel movements, Gastrointestinal dysbiosis and microbiome imbalance, Digestive health support.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}