{"id":"probiotic-lactobacillus-reuteri-prodentis","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild gastrointestinal discomfort"},{"rate":null,"effect":"Oral irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"L. reuteri Prodentis produces reuterin and other bacteriocins that directly inhibit the growth of periodontal pathogens such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. The strain also modulates the host immune response by promoting anti-inflammatory cytokine production and strengthening the oral epithelial barrier, thereby reducing gum inflammation and bleeding.","oneSentence":"Lactobacillus reuteri Prodentis is a probiotic strain that colonizes the oral cavity and produces antimicrobial compounds to inhibit pathogenic bacteria and reduce oral inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:35.686Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gingivitis and periodontal disease"},{"name":"Oral inflammation and gum bleeding"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Probiotic (Lactobacillus reuteri Prodentis","genericName":"Probiotic (Lactobacillus reuteri Prodentis","companyName":"Universidad de Colima","companyId":"universidad-de-colima","modality":"Biologic","firstApprovalDate":"","aiSummary":"Lactobacillus reuteri Prodentis is a probiotic strain that colonizes the oral cavity and produces antimicrobial compounds to inhibit pathogenic bacteria and reduce oral inflammation. Used for Gingivitis and periodontal disease, Oral inflammation and gum bleeding.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}