{"id":"pro-thrombin-concentrate-complex","safety":{"commonSideEffects":[{"rate":null,"effect":"Thromboembolism (venous thromboembolism, myocardial infarction, stroke)"},{"rate":null,"effect":"Disseminated intravascular coagulation (DIC)"},{"rate":null,"effect":"Allergic/hypersensitivity reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL6068614","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PCC is a pooled plasma-derived product containing the vitamin K-dependent factors II, VII, IX, and X (4-factor PCC) or factors II, VII, IX, X plus protein C and S (activated PCC). It rapidly reverses anticoagulation caused by warfarin or other vitamin K antagonists by replenishing depleted clotting factors, thereby restoring the extrinsic and common coagulation pathways.","oneSentence":"Prothrombin Complex Concentrate (PCC) replaces deficient vitamin K-dependent clotting factors (II, VII, IX, X) to restore coagulation cascade function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:09.981Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of warfarin-induced anticoagulation in patients with serious or life-threatening bleeding"},{"name":"Urgent reversal of vitamin K antagonist anticoagulation"}]},"trialDetails":[{"nctId":"NCT03218722","phase":"PHASE3","title":"Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma","status":"COMPLETED","sponsor":"University Hospital, Grenoble","startDate":"2017-12-29","conditions":"Shock, Hemorrhagic","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["KANOKAD"],"phase":"phase_3","status":"active","brandName":"Pro-Thrombin Concentrate Complex","genericName":"Pro-Thrombin Concentrate Complex","companyName":"University Hospital, Grenoble","companyId":"university-hospital-grenoble","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prothrombin Complex Concentrate (PCC) replaces deficient vitamin K-dependent clotting factors (II, VII, IX, X) to restore coagulation cascade function. Used for Reversal of warfarin-induced anticoagulation in patients with serious or life-threatening bleeding, Urgent reversal of vitamin K antagonist anticoagulation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}