{"id":"pro-148","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PRO-148 is developed by Laboratorios Sophia for treatment of dry eye disease and related ocular surface conditions. The drug targets inflammatory pathways involved in ocular surface disease, though the precise molecular mechanism has not been widely disclosed in public literature.","oneSentence":"PRO-148 is an ophthalmic anti-inflammatory agent designed to reduce ocular surface inflammation and associated symptoms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:30:16.859Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease"}]},"trialDetails":[{"nctId":"NCT01541891","phase":"PHASE2","title":"Efficacy and Safety of PRO-148 Ophthalmic Solution Versus SYSTANE® in the Treatment of Patients With Dry Eye Syndrome","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2011-10","conditions":"Dry Eye Syndrome","enrollment":30},{"nctId":"NCT01657253","phase":"PHASE3","title":"Efficacy and Safety of PRO-148 Versus Systane®, in Patients With Mild to Moderate Dry Eye","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2013-11","conditions":"Dry Eye","enrollment":183}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PRO-148 (xanthan gum and sulphate chondroitin)"],"phase":"phase_3","status":"active","brandName":"PRO-148","genericName":"PRO-148","companyName":"Laboratorios Sophia S.A de C.V.","companyId":"laboratorios-sophia-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PRO-148 is an ophthalmic anti-inflammatory agent designed to reduce ocular surface inflammation and associated symptoms. Used for Dry eye disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}