{"id":"pristinamycin-xrp7263","brandName":"PRISTINAMYCIN XRP7263","genericName":"PRISTINAMYCIN XRP7263","companyId":"sanofi","companyName":"Sanofi","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Pyostacine ®"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Pristinamycin (XRP7263), developed by Sanofi, is a broad-spectrum antibiotic with activity against Gram-positive bacteria. It has been studied for treating acute community-acquired pneumonia but lacks an FDA label. One terminated Phase 4 trial compared it to amoxicillin.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pristinamycin is a streptogramin-type macrolide antibiotic composed of two components (pristinamycin I and II) that work synergistically to inhibit bacterial protein synthesis. It binds to the bacterial 50S ribosomal subunit, preventing peptide bond formation and translation. This bactericidal activity makes it effective against a range of gram-positive bacteria and some gram-negative organisms.","oneSentence":"Pristinamycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"trials":[],"indications":{"approved":[{"name":"Bacterial infections caused by susceptible gram-positive organisms"},{"name":"Respiratory tract infections"},{"name":"Skin and soft tissue infections"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}