{"id":"prismocitrate-18","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypocalcemia"},{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Citrate accumulation (in hepatic dysfunction)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prismocitrate 18 chelates ionized calcium in the blood, preventing coagulation during dialysis or other extracorporeal treatments. The citrate is metabolized by the liver to bicarbonate, restoring systemic calcium levels post-treatment. This approach provides anticoagulation localized to the extracorporeal circuit while minimizing systemic anticoagulation effects.","oneSentence":"Prismocitrate 18 is a citrate-based anticoagulant used in regional citrate anticoagulation (RCA) for extracorporeal therapies.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:16.612Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional citrate anticoagulation for continuous renal replacement therapy (CRRT) in critically ill patients"},{"name":"Anticoagulation for extracorporeal blood purification therapies"}]},"trialDetails":[{"nctId":"NCT05399537","phase":"PHASE3","title":"Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT","status":"RECRUITING","sponsor":"Vantive Health LLC","startDate":"2024-07-12","conditions":"Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury (AKI)","enrollment":40},{"nctId":"NCT02860130","phase":"PHASE3","title":"Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)","status":"TERMINATED","sponsor":"Vantive Health LLC","startDate":"2016-09-27","conditions":"Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury","enrollment":34},{"nctId":"NCT01269112","phase":"PHASE4","title":"Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2010-11","conditions":"Acute Kidney Injury","enrollment":103},{"nctId":"NCT02194569","phase":"NA","title":"Magnesium Balance of Citrate-based Continuous Venovenous Hemofiltration, Effect of Citrate Dose.","status":"COMPLETED","sponsor":"Ziekenhuis Oost-Limburg","startDate":"2014-07","conditions":"Critically Ill, Acute Kidney Injury","enrollment":36},{"nctId":"NCT01921816","phase":"NA","title":"A Study on the Efficacy and Safety of Continuous Renal Replacement Therapy (CVVHDF) Using a Commercial Citrate-containing Replacement Fluid (Prismocitrate 18/0)","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2012-05","conditions":"Renal Failure","enrollment":35}],"_emaApprovals":[],"_faersSignals":[{"count":5,"reaction":"CONTRAINDICATION TO MEDICAL TREATMENT"},{"count":5,"reaction":"GENERAL PHYSICAL HEALTH DETERIORATION"}],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Regional Citrate Anticoagulation (RCA)"],"phase":"phase_3","status":"active","brandName":"Prismocitrate 18","genericName":"Prismocitrate 18","companyName":"Vantive Health LLC","companyId":"vantive-health-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prismocitrate 18 is a citrate-based anticoagulant used in regional citrate anticoagulation (RCA) for extracorporeal therapies. Used for Regional citrate anticoagulation for continuous renal replacement therapy (CRRT) in critically ill patients, Anticoagulation for extracorporeal blood purification therapies.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}