{"id":"primaquine-pq-plus-sp-as","safety":{"commonSideEffects":[{"rate":null,"effect":"Hemolysis (in G6PD-deficient patients)"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Methemoglobinemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Primaquine is an 8-aminoquinoline that targets hypnozoites (dormant parasites in the liver) and gametocytes, preventing relapse and transmission. When combined with SP+AS (sulfadoxine-pyrimethamine plus artesunate), a synergistic antimalarial regimen is created: artesunate rapidly clears blood-stage parasites, while SP provides sustained schizontocidal activity, and primaquine eliminates the reservoir of latent parasites and sexual stages.","oneSentence":"Primaquine plus sulfadoxine-pyrimethamine and artesunate works by killing malaria parasites at multiple lifecycle stages, including the dormant liver forms that cause relapse.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:51:58.026Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plasmodium vivax malaria with relapse prevention"},{"name":"Malaria transmission reduction and elimination"}]},"trialDetails":[{"nctId":"NCT02831023","phase":"PHASE2","title":"Phase 2 Efficacy Study of Primaquine and Methylene Blue","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-07","conditions":"Malaria","enrollment":80},{"nctId":"NCT00959517","phase":"PHASE2","title":"Trial of Artesunate Combination Therapy in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-07","conditions":"Uncomplicated Falciparum Malaria","enrollment":588},{"nctId":"NCT00330902","phase":"PHASE3","title":"Randomized Trial of Two Antimalarial Treatments for Clearing Low Density P.Falciparum Parasitaemia in Sudan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2004-01","conditions":"Plasmodium Infections","enrollment":104}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"primaquine (PQ) plus SP+AS","genericName":"primaquine (PQ) plus SP+AS","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Primaquine plus sulfadoxine-pyrimethamine and artesunate works by killing malaria parasites at multiple lifecycle stages, including the dormant liver forms that cause relapse. Used for Plasmodium vivax malaria with relapse prevention, Malaria transmission reduction and elimination.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}