{"id":"prilocaine-hcl-2-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiovascular effects at high doses)"},{"rate":null,"effect":"Local reactions at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prilocaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the generation and propagation of action potentials in sensory and motor nerves, producing localized anesthesia. It is commonly used for infiltration anesthesia, nerve blocks, and topical anesthesia in clinical settings.","oneSentence":"Prilocaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:40.858Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia"},{"name":"Nerve blocks"},{"name":"Topical anesthesia for minor surgical and dental procedures"}]},"trialDetails":[{"nctId":"NCT06899438","phase":"NA","title":"Does Botulinum Toxin Type-A Injection an Effective Way of Relieving Pain in Myofascial Pain Syndrome Patients or Not","status":"COMPLETED","sponsor":"Bursa City Hospital","startDate":"2009-08-26","conditions":"Myofacial Pain Syndromes","enrollment":38},{"nctId":"NCT04756050","phase":"PHASE4","title":"Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function","status":"COMPLETED","sponsor":"Bozyaka Training and Research Hospital","startDate":"2021-02-16","conditions":"Phrenic Nerve Paralysis, Diaphragm Sellae Meningioma, Complications","enrollment":90},{"nctId":"NCT05877690","phase":"NA","title":"Selective Spinal Anaesthesia With Hyperbaric Prilocain With 2%Provides Better Perioperative Hemodynamic Stability for Patients With Peripheral Vascular Disease and Cardiac Dysfunction in Lower Limb Surgery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2023-10","conditions":"Hemodynamic Stability","enrollment":80},{"nctId":"NCT04784104","phase":"PHASE4","title":"Comparison of Infraclavicular And Supraclavicular Block","status":"UNKNOWN","sponsor":"Bozyaka Training and Research Hospital","startDate":"2021-03-05","conditions":"Anesthesia Conduction, Upper Extremity Surgery, Pain, Postoperative","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["priloc %2"],"phase":"marketed","status":"active","brandName":"Prilocaine HCl % 2 injectable solution","genericName":"Prilocaine HCl % 2 injectable solution","companyName":"Bozyaka Training and Research Hospital","companyId":"bozyaka-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prilocaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia, Nerve blocks, Topical anesthesia for minor surgical and dental procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}