{"id":"prilocaine-0-66","safety":{"commonSideEffects":[{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiovascular effects at high doses)"},{"rate":null,"effect":"Local tissue irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prilocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action blocks the conduction of nerve impulses in sensory, motor, and autonomic nerves, resulting in local anesthesia. The drug is metabolized hepatically and has a relatively rapid onset and intermediate duration of action.","oneSentence":"Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:37.805Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve blocks, and topical application"}]},"trialDetails":[{"nctId":"NCT02820688","phase":"PHASE4","title":"Concentration-Volume Relationship in Infraclavicular Block","status":"COMPLETED","sponsor":"Bozyaka Training and Research Hospital","startDate":"2016-06","conditions":"Brachial Plexus Blockade","enrollment":81}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Citanest"],"phase":"marketed","status":"active","brandName":"Prilocaine 0.66%","genericName":"Prilocaine 0.66%","companyName":"Bozyaka Training and Research Hospital","companyId":"bozyaka-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local anesthesia for infiltration, nerve blocks, and topical application.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}