{"id":"pridinol","rwe":[{"pmid":"41827124","year":"2026","title":"Efficacy and Tolerability of Pridinol Mesylate Versus Quinine Sulfate in the Treatment of Nocturnal Leg Cramps: A Propensity Score-Matched Real-World Analysis of Depersonalized 4-Week Data from the German Pain e-Registry (PRISCILA Study).","finding":"","journal":"Journal of clinical medicine","studyType":"Clinical Study"},{"pmid":"41065090","year":"2026","title":"Plasma and Urine Pharmacokinetics of Intravenous Pridinol in Thoroughbreds for Its Medication Control.","finding":"","journal":"Journal of veterinary pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"40295698","year":"2025","title":"High performance thin layer chromatography with eluents containing SDS aided by UV- and Raman spectroscopy.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"39911667","year":"2024","title":"Effectiveness rehabilitative therapy and Pridinol Mesylate in low back pain.","finding":"","journal":"Frontiers in medicine","studyType":"Clinical Study"},{"pmid":"36912069","year":"2023","title":"Concurrent Determination of Pridinol, Diclofenac and Impurity A by HPLC-UV.","finding":"","journal":"Journal of chromatographic science","studyType":"Clinical Study"}],"tags":[{"label":"pridinol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Muscarinic acetylcholine receptor M1","category":"target"},{"label":"CHRM1","category":"gene"},{"label":"CHRM4","category":"gene"},{"label":"CHRM3","category":"gene"},{"label":"M03BX03","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["pridinol","pridinol methanesulfonate salt","pridinol methanesulfonate"],"offLabel":[],"synonyms":["pridinol","pridinol methanesulfonate salt","pridinol methanesulfonate"],"timeline":[],"aiSummary":"Pridinol is a small molecule drug used in the treatment of conditions such as spondyloarthropathy, specifically lumbar spondylarthrosis and chronic low back pain. It is administered through drug therapy, often in conjunction with rehabilitation.","approvals":[],"ecosystem":[],"mechanism":{"target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","targets":[{"gene":"CHRM1","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M1","protein":"Muscarinic acetylcholine receptor M1"},{"gene":"CHRM4","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M4","protein":"Muscarinic acetylcholine receptor M4"},{"gene":"CHRM3","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M3","protein":"Muscarinic acetylcholine receptor M3"},{"gene":"CHRM2","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M2","protein":"Muscarinic acetylcholine receptor M2"},{"gene":"CHRM5","source":"DrugCentral","target":"Muscarinic acetylcholine receptor M5","protein":"Muscarinic acetylcholine receptor M5"}],"modality":"Small Molecule","drugClass":"pridinol","explanation":"Imagine your muscles have a 'brake' that helps them relax. Pridinol works by activating this 'brake', which helps to reduce muscle spasms and pain. This can be especially helpful for people with conditions like muscle cramps or spasms.","oneSentence":"Pridinol works by binding to the muscarinic acetylcholine receptor M1, which helps to relax muscles and reduce muscle spasms.","technicalDetail":"Pridinol exerts its effects by selectively binding to the M1 muscarinic acetylcholine receptor, a subtype of the muscarinic acetylcholine receptor family, which is involved in the regulation of smooth muscle tone and neurotransmitter release."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2263","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PRIDINOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PRIDINOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:28:26.546870","biosimilars":[],"competitors":[{"drugName":"baclofen","drugSlug":"baclofen","fdaApproval":"1977-11-22","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tizanidine","drugSlug":"tizanidine","fdaApproval":"1996-11-27","patentExpiry":"May 7, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cyclobenzaprine","drugSlug":"cyclobenzaprine","fdaApproval":"1977-08-26","patentExpiry":"Mar 14, 2034","patentStatus":"Patent protected","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"pridinol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"baclofen","brandName":"baclofen","genericName":"baclofen","approvalYear":"1977","relationship":"same-class"},{"drugId":"tizanidine","brandName":"tizanidine","genericName":"tizanidine","approvalYear":"1996","relationship":"same-class"},{"drugId":"cyclobenzaprine","brandName":"cyclobenzaprine","genericName":"cyclobenzaprine","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06252064","phase":"NA","title":"Rehabilitative Therapy and Pridinol in Patients With Lumbar Spondylarthrosis and Chronic Low Back Pain","status":"COMPLETED","sponsor":"University of Palermo","startDate":"2022-03-01","conditions":["Spondyloarthropathy"],"enrollment":86,"completionDate":"2024-01-15"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006583","UNII":"9E75Q6SUUB","CHEBI":"CHEBI:75247","INN_ID":"1320","RXNORM":"34479","UMLSCUI":"C0071968","ChEMBL_ID":"CHEMBL404215","KEGG_DRUG":"D08418","DRUGBANK_ID":"DB13642","PUBCHEM_CID":"4904","MESH_SUPPLEMENTAL_RECORD_UI":"C009185"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":26,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"M03BX03","allCodes":["M03BX03","M03BX53"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 24","pmid":"41827124","title":"Efficacy and Tolerability of Pridinol Mesylate Versus Quinine Sulfate in the Treatment of Nocturnal Leg Cramps: A Propensity Score-Matched Real-World Analysis of Depersonalized 4-Week Data from the German Pain e-Registry (PRISCILA Study).","journal":"Journal of clinical medicine"},{"date":"2026 Jan","pmid":"41065090","title":"Plasma and Urine Pharmacokinetics of Intravenous Pridinol in Thoroughbreds for Its Medication Control.","journal":"Journal of veterinary pharmacology and therapeutics"},{"date":"2025 Apr 28","pmid":"40295698","title":"High performance thin layer chromatography with eluents containing SDS aided by UV- and Raman spectroscopy.","journal":"Scientific reports"},{"date":"2024","pmid":"39911667","title":"Effectiveness rehabilitative therapy and Pridinol Mesylate in low back pain.","journal":"Frontiers in medicine"},{"date":"2023 Dec 30","pmid":"36912069","title":"Concurrent Determination of Pridinol, Diclofenac and Impurity A by HPLC-UV.","journal":"Journal of chromatographic science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"PRIDINOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}