{"id":"prfm-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Inflammation"},{"rate":null,"effect":"Delayed healing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PRFM is a regenerative medicine approach that concentrates platelets and fibrin from the patient's own blood to create a bioactive matrix. This matrix releases growth factors (PDGF, VEGF, FGF, TGF-β) that stimulate angiogenesis, cell proliferation, and tissue remodeling. The fibrin scaffold provides structural support for new tissue formation and is gradually resorbed as healing progresses.","oneSentence":"PRFM (platelet-rich fibrin matrix) treatment uses autologous platelet-derived growth factors and fibrin scaffolding to promote tissue regeneration and healing.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:30:14.295Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Corneal epithelial defects and ocular surface disease"}]},"trialDetails":[{"nctId":"NCT03898401","phase":"PHASE1","title":"Effect of PRP Injection in Releiving of Symptoms of Senile Vaginitis","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2019-03-18","conditions":"Senile Vaginitis","enrollment":30},{"nctId":"NCT01590238","phase":"PHASE3","title":"Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM)","status":"COMPLETED","sponsor":"The New York Eye & Ear Infirmary","startDate":"2012-05","conditions":"Alopecia","enrollment":15},{"nctId":"NCT00956020","phase":"PHASE1, PHASE2","title":"Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation","status":"COMPLETED","sponsor":"The New York Eye & Ear Infirmary","startDate":"2009-10","conditions":"Aging","enrollment":4},{"nctId":"NCT00874094","phase":"PHASE1, PHASE2","title":"Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds","status":"COMPLETED","sponsor":"The New York Eye & Ear Infirmary","startDate":"2008-04","conditions":"Nasolabial Folds","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":38,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PRFM treatment","genericName":"PRFM treatment","companyName":"The New York Eye & Ear Infirmary","companyId":"the-new-york-eye-ear-infirmary","modality":"Biologic","firstApprovalDate":"","aiSummary":"PRFM (platelet-rich fibrin matrix) treatment uses autologous platelet-derived growth factors and fibrin scaffolding to promote tissue regeneration and healing. Used for Corneal epithelial defects and ocular surface disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}