{"id":"prevenar-and-pneumo23","safety":{"commonSideEffects":[{"rate":"20-50","effect":"Injection site pain, erythema, or swelling"},{"rate":"5-15","effect":"Fever"},{"rate":"5-20","effect":"Myalgia or fatigue"},{"rate":"5-15","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1628401","moleculeType":"Small molecule","molecularWeight":"657.81"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prevenar (pneumococcal conjugate vaccine) contains polysaccharide antigens from pneumococcal serotypes conjugated to a protein carrier, eliciting both T-cell dependent and antibody responses. Pneumo23 (pneumococcal polysaccharide vaccine) contains polysaccharide antigens from 23 pneumococcal serotypes that stimulate B-cell responses. Together, they provide complementary immunological coverage against invasive pneumococcal disease.","oneSentence":"Prevenar and Pneumo23 are pneumococcal conjugate and polysaccharide vaccines that stimulate the immune system to produce antibodies against Streptococcus pneumoniae.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:30:05.392Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of invasive pneumococcal disease in adults and children"},{"name":"Prevention of pneumococcal pneumonia and bacteremia"}]},"trialDetails":[{"nctId":"NCT07425392","phase":"PHASE3","title":"Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Prior Pneumococcal Vaccination","status":"RECRUITING","sponsor":"Vaxcyte, Inc.","startDate":"2026-02-09","conditions":"Pneumococcal Vaccines","enrollment":720},{"nctId":"NCT06177912","phase":"PHASE3","title":"A Clinical Study of the V116 Vaccine for Children and Teenagers 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