{"id":"preservative-free-latanoprost-50-g-ml","safety":{"commonSideEffects":[{"rate":"5–15%","effect":"Increased iris pigmentation (darkening)"},{"rate":"25–35%","effect":"Conjunctival hyperemia (redness)"},{"rate":"3–10%","effect":"Eyelash growth (hypertrichosis)"},{"rate":"5–10%","effect":"Periocular skin darkening"},{"rate":"5–10%","effect":"Eye irritation or discomfort"}]},"_chembl":{"chemblId":"CHEMBL1051","moleculeType":"Small molecule","molecularWeight":"432.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Latanoprost binds to prostaglandin F receptors in the eye and enhances drainage of fluid through the uveoscleral (unconventional) pathway, which accounts for approximately 10% of aqueous humor outflow under normal conditions. By increasing this drainage route, the drug effectively lowers intraocular pressure, making it effective for glaucoma and ocular hypertension. The preservative-free formulation reduces ocular surface irritation and toxicity associated with benzalkonium chloride and other preservatives.","oneSentence":"Latanoprost is a prostaglandin F (FP) receptor agonist that increases uveoscleral outflow of aqueous humor, thereby reducing intraocular pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:29.733Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma"},{"name":"Ocular hypertension"}]},"trialDetails":[{"nctId":"NCT02585375","phase":"PHASE4","title":"Latanoprost Preserved Versus Unpreserved: Effect on Tear Film Thickness as Measured With OCT","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2015-09-17","conditions":"Glaucoma, Ocular Hypertension","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Preservative-free latanoprost 50µg/ml","genericName":"Preservative-free latanoprost 50µg/ml","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Latanoprost is a prostaglandin F (FP) receptor agonist that increases uveoscleral outflow of aqueous humor, thereby reducing intraocular pressure. Used for Open-angle glaucoma, Ocular hypertension.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}