{"id":"preservative-free-0-15-ha","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid is a naturally occurring polysaccharide that acts as a viscoelastic agent, providing lubrication and moisture retention on the cornea and conjunctiva. The preservative-free formulation reduces irritation from chemical preservatives, making it suitable for sensitive eyes or frequent use. HA forms a protective hydrophilic layer that reduces friction and promotes corneal healing.","oneSentence":"Hyaluronic acid (HA) lubricates and protects the ocular surface by mimicking natural tear film components.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:31.681Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye syndrome / keratoconjunctivitis sicca"},{"name":"Ocular surface protection and lubrication"}]},"trialDetails":[{"nctId":"NCT06822608","phase":"PHASE4","title":"Evaluation of Dexpanthenol and Hyaluronic Acid Eye Drops on Corneal Epithelialization After Trans Epithelial PRK","status":"NOT_YET_RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2025-02","conditions":"Corneal Epithelial Wound Healing","enrollment":68},{"nctId":"NCT03888183","phase":"PHASE4","title":"Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease","status":"UNKNOWN","sponsor":"Chang Gung Memorial Hospital","startDate":"2019-04-17","conditions":"Dry Eye","enrollment":334}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Per-Young Eye Drops"],"phase":"marketed","status":"active","brandName":"preservative-free 0.15% HA","genericName":"preservative-free 0.15% HA","companyName":"Chang Gung Memorial Hospital","companyId":"chang-gung-memorial-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyaluronic acid (HA) lubricates and protects the ocular surface by mimicking natural tear film components. Used for Dry eye syndrome / keratoconjunctivitis sicca, Ocular surface protection and lubrication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}