{"id":"preoperative-injection-of-carbon-nanoparticles","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Lymph node staining/discoloration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carbon nanoparticles function as a tracer agent that preferentially accumulates in regional lymph nodes after injection near the surgical site. This allows surgeons to identify and visualize sentinel lymph nodes intraoperatively, enabling more precise lymph node dissection and staging. The particles provide contrast for visual identification without requiring radioactive tracers.","oneSentence":"Carbon nanoparticles are injected preoperatively to accumulate in lymph nodes and provide real-time visualization during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:30:10.443Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sentinel lymph node identification and visualization during cancer surgery"},{"name":"Lymph node mapping in breast cancer, melanoma, and other solid tumors"}]},"trialDetails":[{"nctId":"NCT06791005","phase":"PHASE3","title":"A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With Thyroid Cancer.","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2025-01-01","conditions":"Papillary Thyroid Cancer","enrollment":400},{"nctId":"NCT04482803","phase":"NA","title":"Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for CN+ Breast Cancer","status":"COMPLETED","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2020-09-24","conditions":"Location and Biopsy of Axillary Lymph Nodes","enrollment":159},{"nctId":"NCT05229874","phase":"PHASE2","title":"Effect of CNSI vs. ICG in Lymph Node Tracing During Gastrectomy","status":"UNKNOWN","sponsor":"Hebei Medical University","startDate":"2022-01-20","conditions":"Gastric Cancer","enrollment":96}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Preoperative Injection of Carbon Nanoparticles","genericName":"Preoperative Injection of Carbon Nanoparticles","companyName":"Second Affiliated Hospital of Xi'an Jiaotong University","companyId":"second-affiliated-hospital-of-xi-an-jiaotong-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carbon nanoparticles are injected preoperatively to accumulate in lymph nodes and provide real-time visualization during surgical procedures. Used for Sentinel lymph node identification and visualization during cancer surgery, Lymph node mapping in breast cancer, melanoma, and other solid tumors.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}