{"id":"prenderol","rwe":[{"pmid":"39449508","year":"2024","title":"[Using metabolomics to explore the effects of epigenetic-modification strategies on the metabolites of Acanthus ilicifolius L. endophytic fungi against ovarian cancer].","finding":"","journal":"Se pu = Chinese journal of chromatography","studyType":"Clinical Study"},{"pmid":"13870189","year":"1962","title":"Head shaking and nystagmus produced by 2,2-diethyl, 1,3-propanediol (prenderol) in the rat.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"13363516","year":"1956","title":"Mutual antagonism and synergism between the central effects of nicotine and 2, 2-diethyl-1, 3-propanediol (prenderol).","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"13201478","year":"1954","title":"Some attempts to prolong the duration of action of 2,2-diethyl-1,3-propanediol (prenderol).","finding":"","journal":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association","studyType":"Clinical Study"},{"pmid":"13163224","year":"1954","title":"Effects of mephenesin and prenderol on intellectual functions of mental patients.","finding":"","journal":"Journal of clinical psychology","studyType":"Clinical Study"}],"tags":[{"label":"prenderol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Childhood absence epilepsy","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"2,2-diethyl-1,3-propanediol","offLabel":[],"synonyms":["prenderol","2,2-Diethyl-1,3-propanediol"],"timeline":[],"approvals":[],"brandName":"2,2-Diethyl-1,3-Propanediol","ecosystem":[{"indication":"Childhood absence epilepsy","otherDrugs":[],"globalPrevalence":50000000}],"mechanism":{"modality":"Small Molecule","drugClass":"prenderol","explanation":"Imagine your brain is a busy city with many different streets and intersections. In people with childhood absence epilepsy, the streets get congested, and seizures occur. Prenderol helps to calm down the traffic by adjusting the flow of certain chemical messengers, or neurotransmitters, which helps to reduce the frequency of seizures.","oneSentence":"Prenderol works by modulating the activity of certain neurotransmitters in the brain to reduce seizure frequency.","technicalDetail":"Prenderol is believed to exert its antiepileptic effects by modulating the activity of GABA_A receptors, which are involved in the regulation of neuronal excitability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2259","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=prenderol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:25:19.339637","biosimilars":[],"competitors":[],"genericName":"prenderol","indications":{"approved":[{"name":"Childhood absence epilepsy","source":"DrugCentral","snomedId":50866000,"regulator":"FDA","usPrevalence":3400000,"globalPrevalence":50000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"A40PF8120T","CHEBI":"CHEBI:134759","UMLSCUI":"C2981301","PUBCHEM_CID":"8284"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Nov","pmid":"39449508","title":"[Using metabolomics to explore the effects of epigenetic-modification strategies on the metabolites of Acanthus ilicifolius L. endophytic fungi against ovarian cancer].","journal":"Se pu = Chinese journal of chromatography"},{"date":"1962 May 1","pmid":"13870189","title":"Head shaking and nystagmus produced by 2,2-diethyl, 1,3-propanediol (prenderol) in the rat.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1956 Sep 1","pmid":"13363516","title":"Mutual antagonism and synergism between the central effects of nicotine and 2, 2-diethyl-1, 3-propanediol (prenderol).","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1954 Sep","pmid":"13201478","title":"Some attempts to prolong the duration of action of 2,2-diethyl-1,3-propanediol (prenderol).","journal":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association"},{"date":"1954 Jul","pmid":"13163224","title":"Effects of mephenesin and prenderol on intellectual functions of mental patients.","journal":"Journal of clinical psychology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"2,2-Diethyl-1,3-Propanediol, also known as prenderol, is a small molecule drug in the prenderol class. It is used to treat childhood absence epilepsy, a condition characterized by brief, frequent seizures. The commercial status of prenderol is currently unknown, and it is not clear if it is patented or available as a generic medication. Further information on its pharmacokinetics, safety, and efficacy is needed. As a pharma professional, it is essential to consult the latest clinical data and regulatory information for accurate details.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}